Literature DB >> 11407850

Role of interleukin-1beta in a murine model of otitis media with effusion.

T Watanabe1, T Hirano, M Suzuki, Y Kurono, G Mogi.   

Abstract

To clarify the role of interleukin-1beta (IL-1beta) in the pathogenesis of otitis media with effusion (OME), we developed and investigated a murine model of this disease. Specific pathogen-free male BALB/c mice received intratympanic injections of 20 microg of endotoxin derived from nontypeable Haemophilus influenzae. Three days after injection, middle ear effusions were observed through the eardrum. Similar pathological changes were observed after inoculation with 100 ng of recombinant IL-1beta. Anti-IL-1 receptor antibodies inhibited the pathological changes induced by the endotoxin. In situ hybridization showed expression of IL-1beta messenger RNA in the epithelium of the middle ear mucosa. These results suggest that IL-1beta might be associated with endotoxin-induced inflammation in the middle ear and might play an important role in the induction of otitis media with effusion.

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Year:  2001        PMID： 11407850     DOI： 10.1177/000348940111000613

Source DB:  PubMed          Journal:  Ann Otol Rhinol Laryngol        ISSN： 0003-4894            Impact factor:   1.547


  9 in total

1.  Effects of Allergina on the treatment of otitis media with effusions.

Authors:  Hyun-Ja Jeong; Seung-Heon Hong; Sung-Chul Kim; Eun-Jeong Park; Chul-Ho Jang; Kyung-Suk Kim; Hyung-Min Kim
Journal:  Inflammation       Date:  2002-04       Impact factor: 4.092

2.  The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media.

Authors:  Arwa Kurabi; Jasmine Lee; Chelsea Wong; Kwang Pak; Hal M Hoffman; Allen F Ryan; Stephen I Wasserman
Journal:  Innate Immun       Date:  2014-03-20       Impact factor: 2.680

3.  Pro-inflammatory interleukins in middle ear effusions from atopic and non-atopic children with chronic otitis media with effusion.

Authors:  Beata Zielnik-Jurkiewicz; Wanda Stankiewicz-Szymczak
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-06-16       Impact factor: 2.503

Review 4.  Mouse models for human otitis media.

Authors:  Dennis R Trune; Qing Yin Zheng
Journal:  Brain Res       Date:  2009-03-06       Impact factor: 3.252

Review 5.  Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media.

Authors:  Arwa Kurabi; Kwang Pak; Allen F Ryan; Stephen I Wasserman
Journal:  Curr Allergy Asthma Rep       Date:  2016-01       Impact factor: 4.806

6.  Blocking macrophage migration inhibitory factor activity alleviates mouse acute otitis media in vivo.

Authors:  Jin Zhang; Min Xu; Qingyin Zheng; Yan Zhang; Weijun Ma; Zhaoqiang Zhang
Journal:  Immunol Lett       Date:  2014-08-06       Impact factor: 3.685

7.  Cytokine levels in groups of patients with different duration of chronic secretory otitis.

Authors:  Svjetlana Matković; Danilo Vojvodić; Ivan Baljosevic
Journal:  Eur Arch Otorhinolaryngol       Date:  2007-07-21       Impact factor: 2.503

Review 8.  Mouse models as a tool to unravel the genetic basis for human otitis media.

Authors:  Qing Yin Zheng; Rachel Hardisty-Hughes; Steve D M Brown
Journal:  Brain Res       Date:  2006-05-26       Impact factor: 3.252

9.  The role of inflammatory mediators in the pathogenesis of otitis media and sequelae.

Authors:  Steven K Juhn; Min-Kyo Jung; Mark D Hoffman; Brian R Drew; Diego A Preciado; Nicholas J Sausen; Timothy T K Jung; Bo Hyung Kim; Sang-Yoo Park; Jizhen Lin; Frank G Ondrey; David R Mains; Tina Huang
Journal:  Clin Exp Otorhinolaryngol       Date:  2008-09-30       Impact factor: 3.372
  9 in total

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