OBJECTIVE: To determine whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) independently of the HLA-DRB1 shared epitope (SE). METHODS: Fifty-four Spanish families with an affected son or daughter and 211 consecutive RA patients were genotyped for HLA-DRB1, tumor necrosis factor a/b microsatellite alleles, and MICA transmembrane polymorphism. We performed a case-control comparison with the consecutive patients and an independent transmission disequilibrium test with the families. RESULTS: The frequency of the MICA 6.0 allele was significantly reduced, compared with controls, in the group of SE+ patients (odds ratio 0.39, P = 0.0005). Additionally, the haplotypes containing this allele were preferentially not transmitted to the affected offspring (9 transmitted of 33; P = 0.007), independent of the presence or absence of an SE either in the same haplotype or in the other haplotype in the progenitor. CONCLUSION: These data suggest that the MICA 6.0 allele is an independent marker of protection against RA in the SE+ group of RA patients.
OBJECTIVE: To determine whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) independently of the HLA-DRB1 shared epitope (SE). METHODS: Fifty-four Spanish families with an affected son or daughter and 211 consecutive RApatients were genotyped for HLA-DRB1, tumor necrosis factor a/b microsatellite alleles, and MICA transmembrane polymorphism. We performed a case-control comparison with the consecutive patients and an independent transmission disequilibrium test with the families. RESULTS: The frequency of the MICA 6.0 allele was significantly reduced, compared with controls, in the group of SE+ patients (odds ratio 0.39, P = 0.0005). Additionally, the haplotypes containing this allele were preferentially not transmitted to the affected offspring (9 transmitted of 33; P = 0.007), independent of the presence or absence of an SE either in the same haplotype or in the other haplotype in the progenitor. CONCLUSION: These data suggest that the MICA 6.0 allele is an independent marker of protection against RA in the SE+ group of RApatients.
Authors: A Martínez; E Sánchez; A Valdivia; G Orozco; M A López-Nevot; D Pascual-Salcedo; A Balsa; B Fernández-Gutiérrez; E G de la Concha; A García-Sánchez; B P C Koeleman; E Urcelay; J Martín Journal: Ann Rheum Dis Date: 2006-02-13 Impact factor: 19.103
Authors: Xiaodong Zhou; Jiucun Wang; Hejian Zou; Michael M Ward; Michael H Weisman; Maribel G Espitia; Xiangjun Xiao; Effie Petersdorf; Emmanuel Mignot; Javier Martin; Lianne S Gensler; Paul Scheet; John D Reveille Journal: Ann Rheum Dis Date: 2013-06-01 Impact factor: 19.103
Authors: Holger Kirsten; Elisabeth Petit-Teixeira; Markus Scholz; Dirk Hasenclever; Helene Hantmann; Dirk Heider; Ulf Wagner; Ulrich Sack; Vitor Hugo Teixeira; Bernard Prum; Jana Burkhardt; Céline Pierlot; Frank Emmrich; François Cornelis; Peter Ahnert Journal: Arthritis Res Ther Date: 2009-05-01 Impact factor: 5.156