Literature DB >> 11406850

Hepatoprotective activity of indigtone--a bioactive fraction from Indigofera tinctoria Linn.

B Singh1, A K Saxena, B K Chandan, V Bhardwaj, V N Gupta, O P Suri, S S Handa.   

Abstract

A bioactive fraction, indigtone (FA), obtained by fractionation of a petroleum ether extract of the aerial parts of Indigofera tinctoria, showed significant dose related hepatoprotective activity against CCl(4) induced liver injury in rats and mice. Hexobarbitone induced 'sleeptime', zoxazolamine induced 'paralysis time', levels of transaminases, bilirubin and total protein in serum were employed as indices of liver injury. Pre and post treatment with FA significantly reversed the majority of the parameters altered by the hepatotoxin. This indicated the preventive and restorative effect of FA in the process of CCl(4) induced liver damage. The fraction possessed a high therapeutic ratio, as no mortality was observed up to a dose of 2 g/kg p.o. in mice. Copyright 2001 John Wiley & Sons, Ltd.

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Year:  2001        PMID： 11406850     DOI： 10.1002/ptr.760

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  4 in total

1.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors:  Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

2.  Modulation of liver and kidney toxicity by herb Withania somnifera for silver nanoparticles: a novel approach for harmonizing between safety and use of nanoparticles.

Authors:  Mohammad F Anwar; Deepak Yadav; Shweta Rastogi; Indu Arora; Roop K Khar; Jagdish Chander; Mohd Samim
Journal:  Protoplasma       Date:  2014-09-24       Impact factor: 3.356

3.  Protective Effects of Cydonia oblonga Mill. Fruit on Carbon Tetrachloride-induced Hepatotoxicity Mediated through Mitochondria and Restoration of Cellular Energy Content.

Authors:  Maryam Noubarani; Shaghayegh Abaei Khayat; Romina Mafinezhad; Mohammad Reza Eskandari; Mohammad Kamalinejad; Sina Andalib; Shohreh Mohebbi
Journal:  Iran J Pharm Res       Date:  2020       Impact factor: 1.696

4.  Evaluation of protective effect of Sapindus mukorossi saponin fraction on CCl(4)-induced acute hepatotoxicity in rats.

Authors:  M Srinivasa Rao; B Syed Asad; Ma Fazil; Rd Sudharshan; Sa Rasheed; Ha Pradeep; S Aboobacker; Ah Thayyil; Ak Riyaz; M Mansoor; Ma Aleem; K Zeeyauddin; M Lakshmi Narasu; A Anjum; M Ibrahim
Journal:  Clin Exp Gastroenterol       Date:  2012-07-17
  4 in total

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