Literature DB >> 11406408

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein.

S T Arold1, A S Baur.   

Abstract

The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.

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Year:  2001        PMID： 11406408     DOI： 10.1016/s0968-0004(01)01846-1

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  56 in total

1.  Neutron reflectometry study of the conformation of HIV Nef bound to lipid membranes.

Authors:  Michael S Kent; Jaclyn K Murton; Darryl Y Sasaki; Sushil Satija; Bulent Akgun; Hirsh Nanda; Joseph E Curtis; Jaroslaw Majewski; Christopher R Morgan; John R Engen
Journal:  Biophys J       Date:  2010-09-22       Impact factor: 4.033

2.  CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable.

Authors:  Kristin Agopian; Bangdong L Wei; J Victor Garcia; Dana Gabuzda
Journal:  Virology       Date:  2006-09-18       Impact factor: 3.616

3.  Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Authors:  Stéphane Betzi; Audrey Restouin; Sandrine Opi; Stefan T Arold; Isabelle Parrot; Françoise Guerlesquin; Xavier Morelli; Yves Collette
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-27       Impact factor: 11.205

4.  Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

Authors:  Eduardo O'Neill; Lillian S Kuo; John F Krisko; Diana R Tomchick; J Victor Garcia; John L Foster
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

5.  Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.

Authors:  Ronald P Trible; Lori Emert-Sedlak; Thomas E Wales; Velpandi Ayyavoo; John R Engen; Thomas E Smithgall
Journal:  J Mol Biol       Date:  2007-09-11       Impact factor: 5.469

6.  HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.

Authors:  Jolie A Leonard; Tracy Filzen; Christoph C Carter; Malinda Schaefer; Kathleen L Collins
Journal:  J Virol       Date:  2011-05-04       Impact factor: 5.103

7.  Effects of HIV-1 Nef on human N-myristoyltransferase 1.

Authors:  Christopher R Morgan; Brian V Miglionico; John R Engen
Journal:  Biochemistry       Date:  2011-03-30       Impact factor: 3.162

8.  Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.

Authors:  John Jeff Alvarado; Sreya Tarafdar; Joanne I Yeh; Thomas E Smithgall
Journal:  J Biol Chem       Date:  2014-08-13       Impact factor: 5.157

9.  Single vector system for efficient N-myristoylation of recombinant proteins in E. coli.

Authors:  Julian M Glück; Silke Hoffmann; Bernd W Koenig; Dieter Willbold
Journal:  PLoS One       Date:  2010-04-09       Impact factor: 3.240

10.  Self-association of the Lentivirus protein, Nef.

Authors:  Youn Tae Kwak; Alexa Raney; Lillian S Kuo; Sarah J Denial; Brenda R S Temple; J Victor Garcia; John L Foster
Journal:  Retrovirology       Date:  2010-09-23       Impact factor: 4.602
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