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Literature DB >> 11406380

Structure and function of the small ribozymes.

Abstract

Recently, major advances have been made toward increasing our understanding of small ribozyme structure and function. The first general acid-base catalytic mechanism for a ribozyme has been defined. Shifted nucleotide pK(a) values have been found to be surprisingly frequent structural elements. Finally, the dynamic nature of RNA catalysis has been highlighted through new structural and biochemical information.

Mesh：

Substances：
RNA, Catalytic

Year: 2001 PMID： 11406380 DOI： 10.1016/s0959-440x(00)00207-4

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

Keyword Cloud
Cited

12 in total

1. Altered structural fluctuations in duplex RNA versus DNA: a conformational switch involving base pair opening.

Authors: Yongping Pan; Alexander D MacKerell
Journal: Nucleic Acids Res Date: 2003-12-15 Impact factor: 16.971

2. Ribozymes: catalytic RNAs that cut things, make things, and do odd and useful jobs.

Authors: Nils G Walter; David R Engelke
Journal: Biologist (London) Date: 2002-10

3. Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme.

Authors: Ricardo Zamel; Alan Poon; Dominic Jaikaran; Angela Andersen; Joan Olive; Diane De Abreu; Richard A Collins
Journal: Proc Natl Acad Sci U S A Date: 2004-01-30 Impact factor: 11.205

Review 4. Ribozyme speed limits.

Authors: Gail Mitchell Emilsson; Shingo Nakamura; Adam Roth; Ronald R Breaker
Journal: RNA Date: 2003-08 Impact factor: 4.942

5. A common speed limit for RNA-cleaving ribozymes and deoxyribozymes.

Authors: Ronald R Breaker; Gail Mitchell Emilsson; Denis Lazarev; Shingo Nakamura; Izabela J Puskarz; Adam Roth; Narasimhan Sudarsan
Journal: RNA Date: 2003-08 Impact factor: 4.942

6. Coordination environment of a site-bound metal ion in the hammerhead ribozyme determined by 15N and 2H ESEEM spectroscopy.

Authors: Matthew Vogt; Simanti Lahiri; Charles G Hoogstraten; R David Britt; Victoria J DeRose
Journal: J Am Chem Soc Date: 2006-12-27 Impact factor: 15.419

Structure and function of the small ribozymes.

1. Altered structural fluctuations in duplex RNA versus DNA: a conformational switch involving base pair opening.

2. Ribozymes: catalytic RNAs that cut things, make things, and do odd and useful jobs.

3. Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme.

Review 4. Ribozyme speed limits.

5. A common speed limit for RNA-cleaving ribozymes and deoxyribozymes.

6. Coordination environment of a site-bound metal ion in the hammerhead ribozyme determined by 15N and 2H ESEEM spectroscopy.

7. Semiautomated model building for RNA crystallography using a directed rotameric approach.

8. Sensing complex regulatory networks by conformationally controlled hairpin ribozymes.

9. Divalent metal ions tune the self-splicing reaction of the yeast mitochondrial group II intron Sc.ai5gamma.

Review 10. Exploring ribozyme conformational changes with X-ray crystallography.