Literature DB >> 11405677

Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules.

Y Hu1, C Li, B A Kulkarni, G Strobel, E Lobkovsky, R M Torczynski, J A Porco.   

Abstract

Enantioselective syntheses of the potent antifungal agent (-)-jesterone, its hydroxy epimer, and a dimeric quinone epoxide derivative are reported. The synthesis involves diastereoselective epoxidation of a chiral quinone monoketal derivative and regio- and stereoselective reduction of a quinone epoxide intermediate.

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Year:  2001        PMID： 11405677     DOI： 10.1021/ol0159367

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

Review 1.  Bioprospecting for microbial endophytes and their natural products.

Authors:  Gary Strobel; Bryn Daisy
Journal:  Microbiol Mol Biol Rev       Date:  2003-12       Impact factor: 11.056

2.  Total Synthesis of the Aglycone of IB-00208.

Authors:  Daniel Knueppel; Jingyue Yang; Bo Cheng; Douglas Mans; Stephen F Martin
Journal:  Tetrahedron       Date:  2015-09-02       Impact factor: 2.457

3.  A strategy for the late-stage divergent syntheses of scyphostatin analogues.

Authors:  Jacob Y Cha; G Leslie Burnett; Yaodong Huang; Jarrod B Davidson; Thomas R R Pettus
Journal:  J Org Chem       Date:  2011-01-21       Impact factor: 4.354

4.  Natural Products as a Foundation for Drug Discovery.

Authors:  John A Beutler
Journal:  Curr Protoc Pharmacol       Date:  2009-09-01

5.  Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Taradas Sarkar; Carlota Lopez Cara; Olga Cruz Lopez; Maria Dora Carrion; Delia Preti; Manlio Tolomeo; Jan Balzarini; Ernest Hamel
Journal:  Med Chem       Date:  2008-11       Impact factor: 2.745

Review 6.  Dimeric approaches to anti-cancer chemotherapeutics.

Authors:  M K Hadden; B S J Blagg
Journal:  Anticancer Agents Med Chem       Date:  2008-10       Impact factor: 2.505

7.  Diastereoselective dearomatization of resorcinols directed by a lactic acid tether: unprecedented enantioselective access to p-quinols.

Authors:  Lupe H Mejorado; Christophe Hoarau; Thomas R R Pettus
Journal:  Org Lett       Date:  2004-05-13       Impact factor: 6.005

8.  Biosynthesis of Rubellins in Ramularia collo-cygni-Genetic Basis and Pathway Proposition.

Authors:  Francois Dussart; Dorota Jakubczyk
Journal:  Int J Mol Sci       Date:  2022-03-23       Impact factor: 5.923

9.  Novel Homo-Bivalent and Polyvalent Compounds Based on Ligustrazine and Heterocyclic Ring as Anticancer Agents.

Authors:  Jiawen Wang; Ge Hong; Guoliang Li; Wenzhi Wang; Tianjun Liu
Journal:  Molecules       Date:  2019-12-09       Impact factor: 4.411
  9 in total

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