Literature DB >> 11405667

Unnatural natural products from the transannular cyclization of lathyrane diterpenes.

G Appendino1, G C Tron, T Jarevång, O Sterner.   

Abstract

The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.

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Year:  2001        PMID: 11405667     DOI: 10.1021/ol0155541

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  7 in total

1.  Molecular library synthesis using complex substrates: expanding the framework of triterpenoids.

Authors:  Vasily A Ignatenko; Yong Han; Gregory P Tochtrop
Journal:  J Org Chem       Date:  2013-01-10       Impact factor: 4.354

2.  Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams.

Authors:  Chong Han; Sathish Rangarajan; Alicia C Voukides; Aaron B Beeler; Richard Johnson; John A Porco
Journal:  Org Lett       Date:  2009-01-15       Impact factor: 6.005

3.  Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.

Authors:  Jing Li; Justin S Cisar; Cong-Ying Zhou; Brunilda Vera; Howard Williams; Abimael D Rodríguez; Benjamin F Cravatt; Daniel Romo
Journal:  Nat Chem       Date:  2013-05-19       Impact factor: 24.427

4.  Remodelling of the natural product fumagillol employing a reaction discovery approach.

Authors:  Bradley R Balthaser; Meghan C Maloney; Aaron B Beeler; John A Porco; John K Snyder
Journal:  Nat Chem       Date:  2011-12       Impact factor: 24.427

5.  Late Stage Azidation of Complex Molecules.

Authors:  Rashad R Karimov; Ankit Sharma; John F Hartwig
Journal:  ACS Cent Sci       Date:  2016-10-07       Impact factor: 14.553

6.  Characterization of the complete chloroplast genome of Euphorbia lathyris (Euphorbiaceae), a traditional Chinese medicine.

Authors:  Xueyan Zhao; Qing Wang; Fangyuan Wang; Yan Li
Journal:  Mitochondrial DNA B Resour       Date:  2020-05-20       Impact factor: 0.658

7.  Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine.

Authors:  Karthik Govindaraju; Marco Masi; Margaux Colin; Veronique Mathieu; Antonio Evidente; Todd W Hudnall; Alexander Kornienko
Journal:  Molecules       Date:  2018-01-28       Impact factor: 4.411

  7 in total

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