| Literature DB >> 11405643 |
Y P Ho1, K K To, S C Au-Yeung, X Wang, G Lin, X Han.
Abstract
A combination of demethylcantharidin, a modified component of a traditional Chinese medicine (TCM), with a platinum moiety has produced a series of TCM-based platinum compounds [Pt(C(8)H(8)O(5))(NH(2)R)(2)] 1-5, which demonstrate selective cytotoxicity toward SK-Hep-1 (human liver) cell line, and circumvention of cross-resistance. The inclusion of demethylcantharidin rendered the compounds highly active as protein phosphatase (PP2A) inhibitors. The new TCM-Pt compounds may possess a novel dual mechanism of antitumor action: inhibition of PP2A and platination of DNA.Entities:
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Year: 2001 PMID： 11405643 DOI： 10.1021/jm000476t
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446