Literature DB >> 11405335

The use of functional genomics in C. elegans for studying human development and disease.

P E Kuwabara1, N O'Neil.   

Abstract

The 100 Mb Caenorhabditis elegans genome sequence is the first animal genome to be sequenced in its entirety. Many reverse-genetics tools have been developed to mine the genome sequence and to facilitate the jump between the identification of a gene sequence and the understanding of its function. Here we discuss how C. elegans can contribute to understanding of the function of genes involved in human development and disease.

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Year:  2001        PMID： 11405335     DOI： 10.1023/a:1010306731764

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  21 in total

1.  The rde-1 gene, RNA interference, and transposon silencing in C. elegans.

Authors:  H Tabara; M Sarkissian; W G Kelly; J Fleenor; A Grishok; L Timmons; A Fire; C C Mello
Journal:  Cell       Date:  1999-10-15       Impact factor: 41.582

2.  The structure of the nervous system of the nematode Caenorhabditis elegans.

Authors:  J G White; E Southgate; J N Thomson; S Brenner
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1986-11-12       Impact factor: 6.237

3.  RNAi in C. elegans: soaking in the genome sequence.

Authors:  H Tabara; A Grishok; C C Mello
Journal:  Science       Date:  1998-10-16       Impact factor: 47.728

4.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors:  A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal:  Nature       Date:  1998-02-19       Impact factor: 49.962

5.  Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.

Authors:  D Levitan; T G Doyle; D Brousseau; M K Lee; G Thinakaran; H H Slunt; S S Sisodia; I Greenwald
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

6.  The embryonic cell lineage of the nematode Caenorhabditis elegans.

Authors:  J E Sulston; E Schierenberg; J G White; J N Thomson
Journal:  Dev Biol       Date:  1983-11       Impact factor: 3.582

7.  Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes.

Authors:  A M Motley; E H Hettema; R Ketting; R Plasterk; H F Tabak
Journal:  EMBO Rep       Date:  2000-07       Impact factor: 8.807

Review 8.  Genome sequence of the nematode C. elegans: a platform for investigating biology.

Authors: 
Journal:  Science       Date:  1998-12-11       Impact factor: 47.728

9.  The genetics of Caenorhabditis elegans.

Authors:  S Brenner
Journal:  Genetics       Date:  1974-05       Impact factor: 4.562

10.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.

Authors:  J Yuan; S Shaham; S Ledoux; H M Ellis; H R Horvitz
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582
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  23 in total

1.  Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.

Authors:  Bitna Yi; James J Sahn; Pooneh Memar Ardestani; Andrew K Evans; Luisa L Scott; Jessica Z Chan; Sangeetha Iyer; Ashley Crisp; Gabriella Zuniga; Jonathan T Pierce; Stephen F Martin; Mehrdad Shamloo
Journal:  J Neurochem       Date:  2017-02       Impact factor: 5.372

Review 2.  Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.

Authors:  Márcio S Baptista; Carlos B Duarte; Patrícia Maciel
Journal:  Cell Mol Life Sci       Date:  2012-03-03       Impact factor: 9.261

3.  Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons.

Authors:  Stefanie Seelk; Irene Adrian-Kalchhauser; Balázs Hargitai; Martina Hajduskova; Silvia Gutnik; Baris Tursun; Rafal Ciosk
Journal:  Elife       Date:  2016-09-07       Impact factor: 8.140

Review 4.  Biochemistry, function, and deficiency of vitamin B12 in Caenorhabditis elegans.

Authors:  Tomohiro Bito; Fumio Watanabe
Journal:  Exp Biol Med (Maywood)       Date:  2016-08-02

Review 5.  C. elegans in high-throughput drug discovery.

Authors:  Linda P O'Reilly; Cliff J Luke; David H Perlmutter; Gary A Silverman; Stephen C Pak
Journal:  Adv Drug Deliv Rev       Date:  2013-12-12       Impact factor: 15.470

6.  Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors.

Authors:  Luisa L Scott; James J Sahn; Antonio Ferragud; Rachel C Yen; Praveen N Satarasinghe; Michael D Wood; Timothy R Hodges; Ted Shi; Brooke A Prakash; Kaitlyn M Friese; Angela Shen; Valentina Sabino; Jonathan T Pierce; Stephen F Martin
Journal:  Neuropsychopharmacology       Date:  2018-04-20       Impact factor: 7.853

7.  Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.

Authors:  Haizhen Wang; Xue Jiang; Jieyu Wu; Linqiang Zhang; Jingfei Huang; Yuru Zhang; Xiaoju Zou; Bin Liang
Journal:  Genetics       Date:  2016-03-26       Impact factor: 4.562

Review 8.  Nutritional Interventions for Mitochondrial OXPHOS Deficiencies: Mechanisms and Model Systems.

Authors:  Adam J Kuszak; Michael Graham Espey; Marni J Falk; Marissa A Holmbeck; Giovanni Manfredi; Gerald S Shadel; Hilary J Vernon; Zarazuela Zolkipli-Cunningham
Journal:  Annu Rev Pathol       Date:  2017-11-03       Impact factor: 23.472

9.  Developmental defects in a Caenorhabditis elegans model for type III galactosemia.

Authors:  Ana M Brokate-Llanos; José M Monje; Piedad Del Socorro Murdoch; Manuel J Muñoz
Journal:  Genetics       Date:  2014-10-08       Impact factor: 4.562

Review 10.  Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.

Authors:  Gary A Silverman; Cliff J Luke; Sangeeta R Bhatia; Olivia S Long; Anne C Vetica; David H Perlmutter; Stephen C Pak
Journal:  Pediatr Res       Date:  2009-01       Impact factor: 3.756
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