Literature DB >> 1140275

Evidence of major role of the intestine in cholesterol synthesis in the adult male rat.

F Chevallier, T Magot.   

Abstract

By an new in vivo method using 1-14-C-acetate, it becomes apparent that the intestine is the main organ concerned in cholesterol synthesis. The liver contributes a mere 13.5% to the total. These results challenge the traditional theory which considers the liver as responsible for producing most of cholesterol synthesized by the rat.

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Year:  1975        PMID： 1140275     DOI： 10.1007/bf01944594

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  [FATE OF CHOLESTEROL FROM CHYLOMICRONS IN THE RAT. 3. MOVEMENTS OF CL4-4-CHOLESTEROL BETWEEN CHYLOMICRONS AND LYMPH OR SERUM IN VIVO].

Authors:  F CHEVALLIER; D MATHE
Journal:  Bull Soc Chim Biol (Paris)       Date:  1964

2.  [The continuous measurement of the specific radioactivity of the expiratory carbon dioxide of an animal after administration of compounds labelled with carbon 14. Detection of isotopic equilibria].

Authors:  F CHEVALLIER; M BRIERE; F SERRELL; M CORNU
Journal:  J Physiol (Paris)       Date:  1962

3.  [Oxidation of acetate 1-C-14 by the rat and discussion of the reconstitution of the acetate and acetyl CoA].

Authors:  M PASCAUD
Journal:  Bull Soc Chim Biol (Paris)       Date:  1963

4.  The intestine is the major site of cholesterol synthesis in the rat.

Authors:  F Chevallier; C Lutton
Journal:  Nat New Biol       Date:  1973-03-14

5.  [Qualitative and quantitative estimation of free and esterified sterols in whole rat and in 23 of its tissues and organs].

Authors:  F d' Hollander; F Chevallier
Journal:  Biochim Biophys Acta       Date:  1969-01-21

6.  [Rates of the process of renewal of cholesterol contained in its transfer space in rats. I. Methods and results obtained in the case of a semi-synthetic control diet].

Authors:  F Chevallier; C Lutton
Journal:  Bull Soc Chim Biol (Paris)       Date:  1966

7.  In vivo demonstration of the circadian thythm of cholesterol biosynthesis in the liver and intestine of the rat.

Authors:  P A Edwards; H Muroya; R G Gould
Journal:  J Lipid Res       Date:  1972-05       Impact factor: 5.922
  7 in total
  1 in total

1.  Effect of the type of diet on the distribution of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in rat small intestine.

Authors:  M Sugano; Y Fujisaki
Journal:  Experientia       Date:  1980-12-15
  1 in total

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