Literature DB >> 11402019

Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination.

L Liu1, K Kang, M Takahara, K D Cooper, M A Ghannoum.   

Abstract

The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.

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Year:  2001        PMID： 11402019      PMCID： PMC98552          DOI： 10.1128/IAI.69.7.4695-4697.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

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9.  Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans.

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Journal:  J Biol Chem       Date:  1998-10-02       Impact factor: 5.157

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  4 in total

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4.  Characterization and partial purification of Candida albicans Secretory IL-12 Inhibitory Factor.

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  4 in total

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