M Lauritsen1, H Ewald. 1. Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital, DK-8240 Risskov, Denmark.
Abstract
OBJECTIVE: To review systematically the empirical evidence for the involvement of genetic risk factors in infantile autism. METHOD: We aimed at including all relevant papers written in English. We conducted a Medline search in September 2000. In addition we searched the reference lists of related papers. RESULTS: A relatively small number of reports including family and twin studies, comorbidity, cytogenetic and molecular genetic studies were reviewed. CONCLUSION: As well family, twin, cytogenetic and molecular genetic studies supported the importance of genetic risk factors in infantile autism. In most individual cases probably at least a few gene variants simultaneously determine the genetic risk. Presently the most interesting chromosome regions concerning the aetiology of autism are chromosomes 7q31-35, 15q11-13 and 16p13.3 which have been suggested by different lines of genetic research.
OBJECTIVE: To review systematically the empirical evidence for the involvement of genetic risk factors in infantile autism. METHOD: We aimed at including all relevant papers written in English. We conducted a Medline search in September 2000. In addition we searched the reference lists of related papers. RESULTS: A relatively small number of reports including family and twin studies, comorbidity, cytogenetic and molecular genetic studies were reviewed. CONCLUSION: As well family, twin, cytogenetic and molecular genetic studies supported the importance of genetic risk factors in infantile autism. In most individual cases probably at least a few gene variants simultaneously determine the genetic risk. Presently the most interesting chromosome regions concerning the aetiology of autism are chromosomes 7q31-35, 15q11-13 and 16p13.3 which have been suggested by different lines of genetic research.
Authors: Marlene B Lauritsen; Anders D Børglum; Catalina Betancur; Anne Philippe; Torben A Kruse; Marion Leboyer; Henrik Ewald Journal: Am J Med Genet Date: 2002-05-08
Authors: Marlene B Lauritsen; Mette Nyegaard; Catalina Betancur; Catherine Colineaux; Trine L Josiassen; Torben A Kruse; Marion Leboyer; Henrik Ewald Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2003-08-15 Impact factor: 3.568