Literature DB >> 11401323

Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase.

P Cuq1, C Rouquet, A Evrard, J Ciccolini, L Vian, J P Cano.   

Abstract

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. Copyright 2001 Cancer Research Campaign.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11401323      PMCID： PMC2363689          DOI： 10.1054/bjoc.2001.1833

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  20 in total

1.  Enhanced antitumor activity of 5-fluorouracil in combination with 2'-deoxyinosine in human colorectal cell lines and human colon tumor xenografts.

Authors:  J Ciccolini; L Peillard; A Evrard; P Cuq; C Aubert; A Pelegrin; P Formento; G Milano; J Catalin
Journal:  Clin Cancer Res       Date:  2000-04       Impact factor: 12.531

2.  An in vitro nucleoside analog screening method for cancer gene therapy.

Authors:  A Evrard; L Vian; C Aubert; J P Cano
Journal:  Cell Biol Toxicol       Date:  1996-12       Impact factor: 6.691

3.  Augmentation of antitumor activity of 5'-deoxy-5-fluorouridine by thymosin fraction 5 in mouse bladder cancer cells in vitro and in vivo.

Authors:  S Ikemoto; K Sugimura; S Wada; R Yasumoto; K Yamamoto; T Kishimoto
Journal:  Cancer Lett       Date:  1999-10-18       Impact factor: 8.679

4.  Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs.

Authors:  Stephen P. Ackland; Godefridus J. Peters
Journal:  Drug Resist Updat       Date:  1999-08       Impact factor: 18.500

5.  Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA.

Authors:  Y Kato; S Matsukawa; R Muraoka; N Tanigawa
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

6.  Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.

Authors:  R D Armstrong; R B Diasio
Journal:  Cancer Res       Date:  1980-09       Impact factor: 12.701

7.  Prediction of response to 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with inoperable advanced gastric cancer by immunostaining of thymidine phosphorylase/platelet-derived endothelial cell growth factor.

Authors:  W Koizumi; K Saigenji; N Nakamaru; I Okayasu; M Kurihara
Journal:  Oncology       Date:  1999-04       Impact factor: 2.935

8.  Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.

Authors:  G J Peters; E Laurensse; A Leyva; J Lankelma; H M Pinedo
Journal:  Cancer Res       Date:  1986-01       Impact factor: 12.701

9.  The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma.

Authors:  H Saito; S Tsujitani; S Oka; A Kondo; M Ikeguchi; M Maeta; N Kaibara
Journal:  Br J Cancer       Date:  1999-10       Impact factor: 7.640

10.  Enhancement of the anti-tumor effect of 5'-deoxy-5-fluorouridine by transfection of thymidine phosphorylase gene into human colon cancer cells.

Authors:  H Kanyama; N Tomita; T Yamano; Y Miyoshi; M Ohue; Y Fujiwara; M Sekimoto; I Sakita; Y Tamaki; M Monden
Journal:  Jpn J Cancer Res       Date:  1999-04
View more
  3 in total

Review 1.  Introduction to the background, principles, and state of the art in suicide gene therapy.

Authors:  Ion Niculescu-Duvaz; Caroline J Springer
Journal:  Mol Biotechnol       Date:  2005-05       Impact factor: 2.695

2.  Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.

Authors:  W Ichikawa; H Uetake; Y Shirota; H Yamada; T Takahashi; Z Nihei; K Sugihara; Y Sasaki; R Hirayama
Journal:  Br J Cancer       Date:  2003-10-20       Impact factor: 7.640

3.  Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity.

Authors:  M de Bruin; T van Capel; K Van der Born; F A Kruyt; M Fukushima; K Hoekman; H M Pinedo; G J Peters
Journal:  Br J Cancer       Date:  2003-03-24       Impact factor: 7.640
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.