BACKGROUND AND AIM: Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers. METHODS: This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured. RESULTS: Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls. CONCLUSION: Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.
BACKGROUND AND AIM: Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers. METHODS: This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured. RESULTS: Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls. CONCLUSION: Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.
Authors: J Lee; S C Ji; B Kim; S Yi; K H Shin; J Y Cho; K S Lim; S H Lee; S H Yoon; J Y Chung; K S Yu; H S Park; S H Kim; I J Jang Journal: Clin Transl Sci Date: 2016-10-26 Impact factor: 4.689
Authors: Yong Lian; Jing Zhao; Peiyu Xu; Yimei Wang; Jun Zhao; Li Jia; Ze Fu; Li Jing; Gang Liu; Shuangqing Peng Journal: PLoS One Date: 2013-08-13 Impact factor: 3.240
Authors: Robert S Wallis; Rodney Dawson; Sven O Friedrich; Amour Venter; Darcy Paige; Tong Zhu; Annette Silvia; Jason Gobey; Craig Ellery; Yao Zhang; Kathleen Eisenach; Paul Miller; Andreas H Diacon Journal: PLoS One Date: 2014-04-14 Impact factor: 3.240