Literature DB >> 11399437

Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors.

J Changeux1, S J Edelstein.   

Abstract

Recent chemical and advanced structural studies on site-directed and naturally occurring pathological mutants of individual members of the multigene family of nicotinic acetylcholine receptors have yielded structure-function relationships supporting indirect 'allosteric' interactions between the acetylcholine-binding sites and the ion channel in signal transduction.

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Year:  2001        PMID： 11399437     DOI： 10.1016/s0959-4388(00)00221-x

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  21 in total

1.  Some properties of human neuronal alpha 7 nicotinic acetylcholine receptors fused to the green fluorescent protein.

Authors:  Eleonora Palma; Anna M Mileo; Ataulfo Martinez-Torres; Fabrizio Eusebi; Ricardo Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

2.  Asymmetric structural motions of the homomeric alpha7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation.

Authors:  Richard H Henchman; Hai-Long Wang; Steven M Sine; Palmer Taylor; J Andrew McCammon
Journal:  Biophys J       Date:  2003-11       Impact factor: 4.033

3.  Acetylcholine nicotinic receptors: finding the putative binding site of allosteric modulators using the "blind docking" approach.

Authors:  Bogdan Iorga; Denyse Herlem; Elvina Barré; Catherine Guillou
Journal:  J Mol Model       Date:  2005-12-22       Impact factor: 1.810

Review 4.  Modulating inhibitory ligand-gated ion channels.

Authors:  Michael Cascio
Journal:  AAPS J       Date:  2006-05-26       Impact factor: 4.009

Review 5.  Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.

Authors:  Mariana Bartos; Jeremías Corradi; Cecilia Bouzat
Journal:  Mol Neurobiol       Date:  2009-10-28       Impact factor: 5.590

Review 6.  Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits.

Authors:  Huibert D Mansvelder; Marjolijn Mertz; Lorna W Role
Journal:  Semin Cell Dev Biol       Date:  2009-01-22       Impact factor: 7.727

7.  Autonomic function in mice lacking alpha5 neuronal nicotinic acetylcholine receptor subunit.

Authors:  Ningshan Wang; Avi Orr-Urtreger; Joab Chapman; Ruth Rabinowitz; Rachel Nachman; Amos D Korczyn
Journal:  J Physiol       Date:  2002-07-15       Impact factor: 5.182

8.  Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.

Authors:  Antoine Taly; Pierre-Jean Corringer; Thomas Grutter; Lia Prado de Carvalho; Martin Karplus; Jean-Pierre Changeux
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-31       Impact factor: 11.205

9.  Binding of long-chain alpha-neurotoxin would stabilize the resting state of nAChR: a comparative study with alpha-conotoxin.

Authors:  Adak Nasiripourdori; Bijan Ranjbar; Hossein Naderi-Manesh
Journal:  Theor Biol Med Model       Date:  2009-02-11       Impact factor: 2.432

10.  Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation.

Authors:  Rodrigo R Resende; Avishek Adhikari
Journal:  Cell Commun Signal       Date:  2009-08-27       Impact factor: 5.712
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