Literature DB >> 11399433

NMDA receptor-mediated dendritic spikes and coincident signal amplification.

J Schiller1, Y Schiller.   

Abstract

Dendrites of cortical neurons possess active conductances, which contribute to the nonlinear processing of synaptic information. Recently it has been shown that basal dendrites can generate highly localized spikes mediated by NMDA receptor channels. These spikes may serve as a powerful mechanism to detect and amplify synchronously activated spatially clustered excitatory synaptic inputs in individual dendritic segments, and may enable parallel processing in several integrative dendritic subunits.

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Year:  2001        PMID: 11399433     DOI: 10.1016/s0959-4388(00)00217-8

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN: 0959-4388            Impact factor:   6.627


  55 in total

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