J I Ishimaru1, N Ogi, S Mizuno, A N Goss. 1. Department of Oral and Maxillofacial Surgery, Gifu Prefectural Gifu Hospital, Japan. ishimaru@ktroad.ne.jp
Abstract
OBJECTIVE: To determine the relationship between synovial fluid, chondroitin sulfate disaccharide and hyaluronic acid to differing degrees of experimental temporomandibular joint (TMJ) osteoarthritis (OA). DESIGN: Twenty-four merino sheep were divided into three groups and had different TMJ surgical procedures to produce OA. Group I; control (six sheep), Group II; disc perforation (nine sheep) and Group III; disc perforation and articular damage (nine sheep). Synovial fluid was collected initially and at sacrifice at 3 months. Chondroitin 4-sulfate, chondroitin 6-sulfate and hyaluronic acid were measured and correlated to the OA histologic score. RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score. CONCLUSION: Chondroitin-sulfate and hyaluronic acid show a correlation with surgically created TMJ osteoarthritis in sheep model. Copyright 2001 OsteoArthritis Research Society International.
OBJECTIVE: To determine the relationship between synovial fluid, chondroitin sulfate disaccharide and hyaluronic acid to differing degrees of experimental temporomandibular joint (TMJ) osteoarthritis (OA). DESIGN: Twenty-four merino sheep were divided into three groups and had different TMJ surgical procedures to produce OA. Group I; control (six sheep), Group II; disc perforation (nine sheep) and Group III; disc perforation and articular damage (nine sheep). Synovial fluid was collected initially and at sacrifice at 3 months. Chondroitin 4-sulfate, chondroitin 6-sulfate and hyaluronic acid were measured and correlated to the OA histologic score. RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score. CONCLUSION:Chondroitin-sulfate and hyaluronic acid show a correlation with surgically created TMJ osteoarthritis in sheep model. Copyright 2001 OsteoArthritis Research Society International.
Authors: Mirna Marques Bezerra; Susan D Brain; Stan Greenacre; Selma Maria Bezerra Jerônimo; Liana Batista de Melo; Julie Keeble; Francisco Airton Castro da Rocha Journal: Br J Pharmacol Date: 2003-12-08 Impact factor: 8.739