Literature DB >> 11397946

In silico mapping of complex disease-related traits in mice.

A Grupe1, S Germer, J Usuka, D Aud, J K Belknap, R F Klein, M K Ahluwalia, R Higuchi, G Peltz.   

Abstract

Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months down to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.

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Year:  2001        PMID： 11397946     DOI： 10.1126/science.1058889

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  119 in total

1.  Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations.

Authors:  M A Hall; P J Norman; B Thiel; H Tiwari; A Peiffer; R W Vaughan; S Prescott; M Leppert; N J Schork; J S Lanchbury
Journal:  Am J Hum Genet       Date:  2002-04-09       Impact factor: 11.025

Review 2.  A toolbox for a small mammal.

Authors:  Philip Avner
Journal:  Mamm Genome       Date:  2002-03       Impact factor: 2.957

Review 3.  A strategy for identifying osteoporosis risk genes.

Authors:  David Rowe; Alexander Lichtler
Journal:  Endocrine       Date:  2002-02       Impact factor: 3.633

Review 4.  Fluoride's effects on the formation of teeth and bones, and the influence of genetics.

Authors:  E T Everett
Journal:  J Dent Res       Date:  2010-10-06       Impact factor: 6.116

5.  Strain screen and haplotype association mapping of wheel running in inbred mouse strains.

Authors:  J Timothy Lightfoot; Larry Leamy; Daniel Pomp; Michael J Turner; Anthony A Fodor; Amy Knab; Robert S Bowen; David Ferguson; Trudy Moore-Harrison; Alicia Hamilton
Journal:  J Appl Physiol (1985)       Date:  2010-06-10

Review 6.  Keeping hopes high.

Authors:  Jocelyne Demengeot; Shohei Hori
Journal:  EMBO Rep       Date:  2003-10-24       Impact factor: 8.807

7.  A strategy for the integration of QTL, gene expression, and sequence analyses.

Authors:  Robert Hitzemann; Barry Malmanger; Cheryl Reed; Maureen Lawler; Barbara Hitzemann; Shannon Coulombe; Kari Buck; Brooks Rademacher; Nicole Walter; Yekatrina Polyakov; James Sikela; Brenda Gensler; Sonya Burgers; Robert W Williams; Ken Manly; Jonathan Flint; Christopher Talbot
Journal:  Mamm Genome       Date:  2003-11       Impact factor: 2.957

8.  Direct molecular haplotyping of long-range genomic DNA with M1-PCR.

Authors:  Chunming Ding; Charles R Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-11       Impact factor: 11.205

Review 9.  Animal models for discovery and assessment of genetic determinants of osteoporosis.

Authors:  Robert J Shmookler Reis; Robert H Ebert
Journal:  Osteoporos Int       Date:  2003-08-29       Impact factor: 4.507

10.  Genomewide analysis of secretory activation in mouse models.

Authors:  Palaniappan Ramanathan; Ian Martin; Peter Thomson; Rosanne Taylor; Christopher Moran; Peter Williamson
Journal:  J Mammary Gland Biol Neoplasia       Date:  2007-11-10       Impact factor: 2.673
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