| Literature DB >> 11397153 |
J F Marcoux1, F A Marcotte, J Wu, P G Dormer, I W Davies, D Hughes, P J Reider.
Abstract
A general preparation of pyridines 4a-f from stabilized ketones 3a-c and aryl ketones 3d-f is described. The annulation of stabilized esters 3g,h gives access to the corresponding 2-pyridones 4g,h. The annulation reactions proceed in fair to excellent yields (46-87%) with vinamidinium hexafluorophosphate salts 2a-d containing electron-withdrawing groups at the beta-position. The mechanism of the reaction was investigated by NMR and proceeds through the formation of a dienaminone intermediate.Entities:
Year: 2001 PMID： 11397153 DOI： 10.1021/jo0155198
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354