BACKGROUND: Tumour necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine associated with cancer-related cachexia. In this study we evaluated serum levels of TNF-alpha in pancreatic cancer patients and investigated their relationships to cachexia. PATIENTS AND METHODS: Serum TNF-alpha levels were determined in 63 patients with pancreatic cancer using an enzyme immunoassay specific for human TNF-alpha. RESULTS: Serum TNF-alpha levels were detected in 36.5% of patients. Patients with metastatic disease showed significantly higher positive serum TNF-alpha rate compared to those with non-metastatic disease. Patients with detectable serum TNF-alpha levels had significantly lower body weight and body mass index, lower haematocrit and haemoglobin values, and lower serum total protein and albumin levels compared to those with undetectable TNF-alpha levels. Serum TNF-alpha levels were inversely correlated with body weight, body mass index, haematocrit, haemoglobin, and serum protein and albumin levels. CONCLUSIONS: TNF-alpha levels are detectable in the serum of pancreatic cancer patients, particularly in those with advanced disease, and these levels correlate with poor nutritional status.
BACKGROUND:Tumour necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine associated with cancer-related cachexia. In this study we evaluated serum levels of TNF-alpha in pancreatic cancerpatients and investigated their relationships to cachexia. PATIENTS AND METHODS: Serum TNF-alpha levels were determined in 63 patients with pancreatic cancer using an enzyme immunoassay specific for humanTNF-alpha. RESULTS: Serum TNF-alpha levels were detected in 36.5% of patients. Patients with metastatic disease showed significantly higher positive serum TNF-alpha rate compared to those with non-metastatic disease. Patients with detectable serum TNF-alpha levels had significantly lower body weight and body mass index, lower haematocrit and haemoglobin values, and lower serum total protein and albumin levels compared to those with undetectable TNF-alpha levels. Serum TNF-alpha levels were inversely correlated with body weight, body mass index, haematocrit, haemoglobin, and serum protein and albumin levels. CONCLUSIONS:TNF-alpha levels are detectable in the serum of pancreatic cancerpatients, particularly in those with advanced disease, and these levels correlate with poor nutritional status.
Authors: Gunisha Sagar; Raghuwansh P Sah; Naureen Javeed; Shamit K Dutta; Thomas C Smyrk; Julie S Lau; Nino Giorgadze; Tamar Tchkonia; James L Kirkland; Suresh T Chari; Debabrata Mukhopadhyay Journal: Gut Date: 2015-04-28 Impact factor: 23.059
Authors: Christophe Van de Wiele; Mathias Van Vlaenderen; Ludovic D'Hulst; Anne Delcourt; Dominique Copin; Bart De Spiegeleer; Alex Maes Journal: Eur J Nucl Med Mol Imaging Date: 2016-10-11 Impact factor: 9.236
Authors: Mazhar Al-Zoubi; Galina Chipitsyna; Shivam Saxena; Konrad Sarosiek; Ankit Gandhi; Christopher Y Kang; Daniel Relles; Jocelyn Andrelsendecki; Terry Hyslop; Charles J Yeo; Hwyda A Arafat Journal: J Gastrointest Surg Date: 2013-10-04 Impact factor: 3.452