Plasmalogen levels in serum from patients with impaired carbohydrate or lipid metabolism and in elderly subjects with normal metabolic values.

The precise role played by plasmalogen phospholipids (PL) of lipoproteins and cell membranes is not well understood. However, they might act as endogenous antioxidants in defending cell membranes and lipoproteins from reactive oxygen species. A decline of plasmalogen concentrations has been observed in some tissues in normal aging and in some pathologic conditions. For healthy adults, we had reported negative correlations of age with serum plasmalogen PL derived heaxadecanal dimethylacetal (16:0DMA) or octadecanal dimethylacetal (18:0DMA) values. To mark off these age associated changes from disturbances in glucose or lipid metabolism, this study compares the 16:0DMA and 18:0DMA data of serum PL from 118 elderly subjects, aged 57-94 years, and grouped according to the disturbance of glucose or lipid metabolism. Using a new synthetic test mixture of 16:0DMA with oleic acid butylester as a quality control in gas chromatography, the highest 16:0DMA values were found in hypercholesterolemic subjects. However, related to the bulk of serum PL, were the plasmalogens possibly act as antioxidants, the highest values of 16:0DMA/PL were found in controls. A negative correlation of serum triglycerides (TG) with 16:0DMA was detected (n=118). The data suggest a closer association of low DMA values with elevated TG levels as compared to elevated plasma glucose or other serum lipid levels.