Literature DB >> 11394856

Natural and synthetic benzophenones: interaction with the cytosolic binding domain of P-glycoprotein.

S Rancon1, A Chaboud, N Darbour, G Comte, C Bayet, P N Simon, J Raynaud, A Di Pietro, P Cabalion, D Barron.   

Abstract

A benzophenone glycoside has been isolated from Davallia solida. Its structure was elucidated by chemical and spectral means as 4-O-beta-D-glucopyranosyl-2,6,4'-trihydroxybenzophenone. It bound with moderate affinity to the purified C-terminal cytosolic domain of P-glycoprotein, but the binding affinity was 6- to 10-fold increased for its aglycone derivative and other related benzophenones.

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Year:  2001        PMID: 11394856     DOI: 10.1016/s0031-9422(01)00120-0

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


  3 in total

1.  Facile Access to Sterically Hindered Aryl Ketones via Carbonylative Cross-Coupling: Application to the Total Synthesis of Luteolin.

Authors:  B Michael O'Keefe; Nicholas Simmons; Stephen F Martin
Journal:  Tetrahedron       Date:  2011-06-17       Impact factor: 2.457

2.  Carbonylative cross-coupling of ortho-disubstituted aryl iodides. convenient synthesis of sterically hindered aryl ketones.

Authors:  B Michael O'Keefe; Nicholas Simmons; Stephen F Martin
Journal:  Org Lett       Date:  2008-10-24       Impact factor: 6.005

Review 3.  Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities.

Authors:  Ari Satia Nugraha; Bawon Triatmoko; Phurpa Wangchuk; Paul A Keller
Journal:  Biomolecules       Date:  2020-01-24
  3 in total

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