| Literature DB >> 11392617 |
S E Hamilton1, S N Hardouin, S G Anagnostaras, G G Murphy, K N Richmond, A J Silva, E O Feigl, N M Nathanson.
Abstract
We used gene targeting to generate mice lacking the M1 muscarinic acetylcholine receptor. These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory.Entities:
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Year: 2001 PMID： 11392617 DOI： 10.1016/s0024-3205(01)01043-8
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037