Literature DB >> 11392552

Anodic oxidation of ifosfamide and cyclophosphamide: a biomimetic metabolism model of the oxazaphosphorinane anticancer drugs.

A Paci1, T Martens, J Royer.   

Abstract

The electrochemical oxidation of anticancer drugs ifosfamide and cyclophosphamide produced in high yield methoxylated analogues of the key hydroxy-metabolites of these oxazaphosphorine prodrugs. The cytotoxicity of these compounds was evaluated, and found to be as high as the hydroxy-metabolite.

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Year:  2001        PMID： 11392552     DOI： 10.1016/s0960-894x(01)00218-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance.

Authors:  Ming Yan; Yu Kawamata; Phil S Baran
Journal:  Chem Rev       Date:  2017-10-09       Impact factor: 60.622

2.  QSAR Studying of Oxidation Behavior of Benzoxazines as an Important Pharmaceutical Property.

Authors:  Elham Baher; Naser Darzi
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

3.  Charged Tags for the Identification of Oxidative Drug Metabolites Based on Electrochemistry and Mass Spectrometry.

Authors:  Alexandra Gutmann; Lars Julian Wesenberg; Nadine Peez; Siegfried R Waldvogel; Thorsten Hoffmann
Journal:  ChemistryOpen       Date:  2020-05-06       Impact factor: 2.911

4.  Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide.

Authors:  Irena R Štenglová Netíková; Luboš Petruželka; Martin Šťastný; Václav Štengl
Journal:  Int J Nanomedicine       Date:  2018-11-26
  4 in total

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