| Literature DB >> 11392545 |
C García-Echeverría1, P Imbach, D France, P Fürst, M Lang, A M Noorani, D Scholz, J Zimmermann, P Furet.
Abstract
We describe the identification and in vitro characterization of a series of 2-aminobenzylstatine derivatives that inhibit non-covalently the chymotrypsin-like activity of the 20S proteasome. Our initial SAR data demonstrate that the 2-aminobenzylstatine core structure can effectively serve as the basis for designing potent, selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome.Entities:
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Year: 2001 PMID： 11392545 DOI： 10.1016/s0960-894x(01)00205-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823