Literature DB >> 11392534

Liver cell specific targeting of peptide nucleic acid oligomers.

X Zhang1, C G Simmons, D R Corey.   

Abstract

Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.

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Year:  2001        PMID： 11392534     DOI： 10.1016/s0960-894x(01)00198-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  PNA Technology.

Authors:  Peter E Nielsen
Journal:  Mol Biotechnol       Date:  2004-03       Impact factor: 2.695

2.  Ligands of the asialoglycoprotein receptor for targeted gene delivery, part 1: Synthesis of and binding studies with biotinylated cluster glycosides containing N-acetylgalactosamine.

Authors:  Ulrika Westerlind; Jacob Westman; Elisabeth Törnquist; C I Edvard Smith; Stefan Oscarson; Martina Lahmann; Thomas Norberg
Journal:  Glycoconj J       Date:  2004       Impact factor: 2.916

3.  Efficiency of cellular delivery of antisense peptide nucleic acid by electroporation depends on charge and electroporation geometry.

Authors:  Mette Joergensen; Birgit Agerholm-Larsen; Peter E Nielsen; Julie Gehl
Journal:  Oligonucleotides       Date:  2011-01-14

4.  Antiproliferative effect in chronic myeloid leukaemia cells by antisense peptide nucleic acids.

Authors:  Valentina Rapozzi; Brigitte E A Burm; Susanna Cogoi; Gijs A van der Marel; Jacques H van Boom; Franco Quadrifoglio; Luigi E Xodo
Journal:  Nucleic Acids Res       Date:  2002-09-01       Impact factor: 16.971

5.  Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs).

Authors:  Christopher J Nulf; David Corey
Journal:  Nucleic Acids Res       Date:  2004-07-19       Impact factor: 16.971

6.  Sequence-specific DNA strand cleavage by 111In-labeled peptide nucleic acids.

Authors:  Yujian He; Igor G Panyutin; Alex Karavanov; Vadim V Demidov; Ronald D Neumann
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-02-05       Impact factor: 9.236

7.  Pharmacokinetic analysis of polyamide nucleic-acid-cell penetrating peptide conjugates targeted against HIV-1 transactivation response element.

Authors:  Sabyasachi Ganguly; Binay Chaubey; Snehlata Tripathi; Alok Upadhyay; Prasad V S V Neti; Roger W Howell; Virendra Nath Pandey
Journal:  Oligonucleotides       Date:  2008-09

8.  Galactose substituted zinc phthalocyanines as near infrared fluorescence probes for liver cancer imaging.

Authors:  Feng Lv; Yanzhou Li; Bo Cao; Tianjun Liu
Journal:  J Mater Sci Mater Med       Date:  2012-11-27       Impact factor: 3.896

9.  Susceptibility of methicillin-resistant Staphylococcus aureus to photodynamic antimicrobial chemotherapy with α-D-galactopyranosyl zinc phthalocyanines: in vitro study.

Authors:  Zhanjuan Zhao; Yanzhou Li; Shuai Meng; Shaozeng Li; Qiong Wang; Tianjun Liu
Journal:  Lasers Med Sci       Date:  2013-11-19       Impact factor: 3.161

10.  Synthesis and cytotoxicity of chalcones and 5-deoxyflavonoids.

Authors:  Jing Zhang; Xin-Ling Fu; Nan Yang; Qiu-An Wang
Journal:  ScientificWorldJournal       Date:  2013-06-06
  10 in total

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