| Literature DB >> 11391722 |
J Petäjä1, E Pesonen, J A Fernández, J H Griffin, H Repo, S E Jansson, A E Vento, O J Rämö.
Abstract
To assess possible interactions between inflammation and activation of the anticoagulant protein C system during post-ischemic reperfusion protein C, APC, neutrophil L-selectin expression and myocardial myeloperoxidase activity (MPO) were measured in 19 patients undergoing cardiopulmonary bypass. After reperfusion for 10 min, APC to protein C ratio (APC/PC) increased from pre-reperfusion value 1.43 +/- 0.12 (mean +/- SEM) to 2.25 +/- 0.29, p = 0.015. Negative correlations were observed between APC/PC and MPO activity (Spearman r -0.64, p = 0.007) and APC/PC and neutrophil L-selectin expression (r = -0.7, p = 0.007, demonstrating that post-ishemic protein C activation was associated with decreased neutrophil tissue sequestration. Thus, physiological protein C activation may be involved in regulation of the inflammatory injury during reperfusion of human ischemic coronary circulation. Copyright 2001 Wiley-Liss, Inc.Entities:
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Year: 2001 PMID： 11391722 DOI： 10.1002/ajh.1110
Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047