Literature DB >> 11391350

Nodular Leydig cell hyperplasia in a boy with familial male-limited precocious puberty.

E W Leschek1, W Y Chan, D A Diamond, M Kaefer, J Jones, K M Barnes, G B Cutler.   

Abstract

In boys with familial male-limited precocious puberty, an activating mutation of the luteinizing hormone receptor causes Leydig cell hyperplasia, resulting in excess testosterone production. There are no reports of Leydig cell masses in boys with familial male-limited precocious puberty. We describe a 10-year-old boy with familial male-limited precocious puberty who developed Leydig cell nodules.

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Year:  2001        PMID： 11391350     DOI： 10.1067/mpd.2001.114477

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  10 in total

1.  Mutation analysis of the LH receptor gene in Leydig cell adenoma and hyperplasia and functional and biochemical studies of activating mutations of the LH receptor gene.

Authors:  Annemieke M Boot; Serge Lumbroso; Miriam Verhoef-Post; Annette Richter-Unruh; Leendert H J Looijenga; Ada Funaro; Auke Beishuizen; André van Marle; Stenvert L S Drop; Axel P N Themmen
Journal:  J Clin Endocrinol Metab       Date:  2011-04-13       Impact factor: 5.958

2.  Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant.

Authors:  Chelsi Flippo; Vipula Kolli; Melissa Andrew; Seth Berger; Tricia Bhatti; Alison M Boyce; Daniel Casella; Michael T Collins; Emmanuèle Délot; Joseph Devaney; Stephen M Hewitt; Thomas Kolon; Ashwini Mallappa; Perrin C White; Deborah P Merke; Andrew Dauber
Journal:  J Endocr Soc       Date:  2022-08-12

3.  Characterization and management of testicular pathology in McCune-Albright syndrome.

Authors:  Alison M Boyce; William H Chong; Thomas H Shawker; Peter A Pinto; W Marsten Linehan; Nisan Bhattacharryya; Maria J Merino; Frederick R Singer; Michael T Collins
Journal:  J Clin Endocrinol Metab       Date:  2012-06-28       Impact factor: 5.958

4.  Precocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene.

Authors:  Stacey R McGee; Prema Narayan
Journal:  Endocrinology       Date:  2013-07-16       Impact factor: 4.736

5.  Ectopic secretion of LH by an endocrine pancreatic tumor.

Authors:  E Brignardello; R Manti; M Papotti; E Allìa; D Campra; G Isolato; M C Cassinis; G Fronda; G Boccuzzi
Journal:  J Endocrinol Invest       Date:  2004-04       Impact factor: 4.256

Review 6.  Hyperplasia in glands with hormone excess.

Authors:  Stephen J Marx
Journal:  Endocr Relat Cancer       Date:  2015-09-25       Impact factor: 5.678

Review 7.  Genetic Models for the Study of Luteinizing Hormone Receptor Function.

Authors:  Prema Narayan
Journal:  Front Endocrinol (Lausanne)       Date:  2015-09-29       Impact factor: 5.555

8.  Hyperglycemia contributes to the development of Leydig cell hyperplasia in male Spontaneously Diabetic Torii rats.

Authors:  Yoshitomi Nakane; Yusuke Kemmochi; Naoto Ogawa; Tomohiko Sasase; Takeshi Ohta; Yoshikazu Higami; Fumio Fukai
Journal:  J Toxicol Pathol       Date:  2020-03-20       Impact factor: 1.628

Review 9.  Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors.

Authors:  Duaa Althumairy; Xiaoping Zhang; Nicholas Baez; George Barisas; Deborah A Roess; George R Bousfield; Debbie C Crans
Journal:  Diseases       Date:  2020-09-15

10.  Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene.

Authors:  Bahar Özcabı; Feride Tahmiscioğlu Bucak; Serdar Ceylaner; Rahşan Özcan; Cenk Büyükünal; Oya Ercan; Beyhan Tüysüz; Olcay Evliyaoğlu
Journal:  J Clin Res Pediatr Endocrinol       Date:  2015-09
  10 in total

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