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Literature DB >> 11390937

UTP as an extracellular signaling molecule.

Abstract

In addition to their central role in many biochemical processes, uridine nucleotides are important extracellular signaling molecules that regulate a broad spectrum of cell functions via activation of P2Y2, P2Y4, and P2Y6 receptors. Cellular release of UTP provides a mechanism for autocrine control of calcium- or protein kinase C-dependent processes.

Entities: Chemical Gene

Mesh：

Substances：
Uridine Triphosphate

Year: 2001 PMID： 11390937 DOI： 10.1152/physiologyonline.2001.16.1.1

Source DB: PubMed Journal: News Physiol Sci ISSN： 0886-1714

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Cited

42 in total

Review 1. Purinergic regulation of epithelial transport.

Authors: R Elaine Bucheimer; Joel Linden
Journal: J Physiol Date: 2003-12-23 Impact factor: 5.182

2. Pharmacological characterization of nucleotide P2Y receptors on endothelial cells of the mouse aorta.

Authors: Pieter-Jan D F Guns; András Korda; Herta M Crauwels; Tim Van Assche; Bernard Robaye; Jean-Marie Boeynaems; Hidde Bult
Journal: Br J Pharmacol Date: 2005-09 Impact factor: 8.739

Review 3. Structure and function of the mucus clearance system of the lung.

Authors: Brenda M Button; Brian Button
Journal: Cold Spring Harb Perspect Med Date: 2013-08-01 Impact factor: 6.915

4. Noradrenaline and extracellular nucleotide cotransmission involves activation of vasoconstrictive P2X(1,3)- and P2Y6-like receptors in mouse perfused kidney.

Authors: Oliver Vonend; Johannes Stegbauer; Johann Sojka; Sina Habbel; Ivo Quack; Bernard Robaye; Jean-Marie Boeynaems; Lars Christian Rump
Journal: Br J Pharmacol Date: 2005-05 Impact factor: 8.739

5. K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon.

Authors: J E Matos; B Robaye; J M Boeynaems; R Beauwens; J Leipziger
Journal: J Physiol Date: 2005-02-17 Impact factor: 5.182

6. UTP-dependent turnover of Trypanosoma brucei mitochondrial mRNA requires UTP polymerization and involves the RET1 TUTase.

Authors: Christopher M Ryan; Laurie K Read
Journal: RNA Date: 2005-04-05 Impact factor: 4.942

UTP as an extracellular signaling molecule.

Review 1. Purinergic regulation of epithelial transport.

2. Pharmacological characterization of nucleotide P2Y receptors on endothelial cells of the mouse aorta.

Review 3. Structure and function of the mucus clearance system of the lung.

4. Noradrenaline and extracellular nucleotide cotransmission involves activation of vasoconstrictive P2X(1,3)- and P2Y6-like receptors in mouse perfused kidney.

5. K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon.

6. UTP-dependent turnover of Trypanosoma brucei mitochondrial mRNA requires UTP polymerization and involves the RET1 TUTase.

7. Endothelium-dependent relaxation evoked by ATP and UTP in the aorta of P2Y2-deficient mice.

8. UTP regulation of ion transport in alveolar epithelial cells involves distinct mechanisms.

9. Purinergic inhibition of Na⁺,K⁺,Cl⁻ cotransport in C11-MDCK cells: Role of stress-activated protein kinases.

10. Spreading dilatation to luminal perfusion of ATP and UTP in rat isolated small mesenteric arteries.