Literature DB >> 11390929

A Novel Pacemaker Mechanism Drives Gastrointestinal Rhythmicity.

Kenton M. Sanders1, Tamás Ördög, Sang Don Koh, Sean M. Ward.   

Abstract

Electric pacemaker activity drives peristaltic and segmental contractions in the gastrointestinal tract. Interstitial cells of Cajal (ICC) are responsible for spontaneous pacemaker activity. ICC remain rhythmic in culture and generate voltage-independent inward currents via a nonselective cation conductance. Ca(2+) release from endoplasmic reticulum and uptake by mitochondria initiates pacemaker currents. This novel mechanism provides the basis for electric rhythmicity in gastrointestinal muscles.

Entities:  

Year:  2000        PMID： 11390929     DOI： 10.1152/physiologyonline.2000.15.6.291

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  22 in total

1.  Diabetes-related alterations in the enteric nervous system and its microenvironment.

Authors:  Mária Bagyánszki; Nikolett Bódi
Journal:  World J Diabetes       Date:  2012-05-15

2.  Roles of interstitial cells of Cajal in intestinal transit and exogenous electrical pacing.

Authors:  Jieyun Yin; Xiaohua Hou; J D Z Chen
Journal:  Dig Dis Sci       Date:  2006-10       Impact factor: 3.199

3.  A biophysically based mathematical model of unitary potential activity in interstitial cells of Cajal.

Authors:  R A Faville; A J Pullan; K M Sanders; N P Smith
Journal:  Biophys J       Date:  2008-03-13       Impact factor: 4.033

4.  Enteric sensory neurons communicate with interstitial cells of Cajal to affect pacemaker activity in the small intestine.

Authors:  Yong Fang Zhu; Xuan-Yu Wang; Bobbi-Jo Lowie; Sean Parsons; Liz White; Wolfgang Kunze; Andrew Pawelka; Jan D Huizinga
Journal:  Pflugers Arch       Date:  2013-10-08       Impact factor: 3.657

5.  Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.

Authors:  R A Faville; A J Pullan; K M Sanders; S D Koh; C M Lloyd; N P Smith
Journal:  Biophys J       Date:  2009-06-17       Impact factor: 4.033

6.  Actin microfilament involved in regulation of pacemaking activity in cultured interstitial cells of Cajal from murine intestine.

Authors:  Zuo Yu Wang; Yan Fei Han; Xu Huang; Hong Li Lu; Xin Guo; Yong Chul Kim; Wen Xie Xu
Journal:  J Membr Biol       Date:  2010-03-27       Impact factor: 1.843

7.  Neurotensin modulates pacemaker activity in interstitial cells of Cajal from the mouse small intestine.

Authors:  Jun Lee; Young Dae Kim; Chan Guk Park; Man Yoo Kim; In Yeoub Chang; Dong Chuan Zuo; Pawan Kumar Shahi; Seok Choi; Cheol Ho Yeum; Jae Yeoul Jun
Journal:  Mol Cells       Date:  2012-03-21       Impact factor: 5.034

8.  Effects of prostaglandin F2α on small intestinal interstitial cells of Cajal.

Authors:  Chan Guk Park; Young Dae Kim; Man Yoo Kim; Jae Woong Koh; Jae Yeoul Jun; Cheol Ho Yeum; Insuk So; Seok Choi
Journal:  World J Gastroenterol       Date:  2011-03-07       Impact factor: 5.742

9.  The effect of SCF and ouabain on small intestinal motility dysfunction induced by gastric cancer peritoneal metastasis.

Authors:  Dan Kong; Jing Li; Baoshan Zhao; Bairong Xia; Lei Zhang; Yan He; Xiuli Wang; Lei Gao; Yufu Wang; Xiaoming Jin; Ge Lou
Journal:  Clin Exp Metastasis       Date:  2015-02-19       Impact factor: 5.150

10.  A Ca(2+)-inhibited non-selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal.

Authors:  Sang Don Koh; Jae Yeoul Jun; Tae Wan Kim; Kenton M Sanders
Journal:  J Physiol       Date:  2002-05-01       Impact factor: 5.182
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