| Literature DB >> 11390897 |
Luis Gabriel Melo1, Stephen C. Pang, Uwe Ackermann.
Abstract
Recent findings in atrial natriuretic peptide (ANP) transgenic and gene knockout mouse models uncovered a tonic vasodilatory effect of this hormone that contributes to chronic blood pressure homeostasis. With elevated salt intake, ANP-mediated antagonism of the renin-angiotensin system is essential for blood pressure constancy, suggesting that a deficiency in ANP activity may underlie the etiology of sodium-retaining disorders.Entities:
Year: 2000 PMID： 11390897 DOI： 10.1152/physiologyonline.2000.15.3.143
Source DB: PubMed Journal: News Physiol Sci ISSN： 0886-1714