Literature DB >> 11390882

The Cell Physiology of Biphasic Insulin Secretion.

Patrik Rorsman1, Lena Eliasson, Erik Renström, Jesper Gromada, Sebastian Barg, Sven Göpel.   

Abstract

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

Entities:  

Year:  2000        PMID： 11390882     DOI： 10.1152/physiologyonline.2000.15.2.72

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  111 in total

Review 1.  Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

Authors:  L S Satin
Journal:  Endocrine       Date:  2000-12       Impact factor: 3.633

2.  Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.

Authors:  S Barg; X Ma; L Eliasson; J Galvanovskis; S O Göpel; S Obermüller; J Platzer; E Renström; M Trus; D Atlas; J Striessnig; P Rorsman
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

3.  Intracellular calcium ion response to glucose in beta-cells of calbindin-D28k nullmutant mice and in betaHC13 cells overexpressing calbindin-D28k.

Authors:  Jai Parkash; Muhammad A Chaudhry; Ayman S Amer; Sylvia Christakos; William B Rhoten
Journal:  Endocrine       Date:  2002-08       Impact factor: 3.633

4.  Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels.

Authors:  Edward K Ainscow; Shirin Mirshamsi; Teresa Tang; Michael L J Ashford; Guy A Rutter
Journal:  J Physiol       Date:  2002-10-15       Impact factor: 5.182

Review 5.  Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles.

Authors:  Jakob Balslev Sørensen
Journal:  Pflugers Arch       Date:  2004-03-02       Impact factor: 3.657

6.  Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

Authors:  Sven Göpel; Quan Zhang; Lena Eliasson; Xiao-Song Ma; Juris Galvanovskis; Takahiro Kanno; Albert Salehi; Patrik Rorsman
Journal:  J Physiol       Date:  2004-02-13       Impact factor: 5.182

7.  Synapsins I and II are not required for β-cell insulin secretion: granules must pool their own weight.

Authors:  L S Satin
Journal:  Endocrinology       Date:  2012-05       Impact factor: 4.736

8.  Ultra-structural study of insulin granules in pancreatic β-cells of db/db mouse by scanning transmission electron microscopy tomography.

Authors:  Yanhong Xue; Wei Zhao; Wen Du; Xiang Zhang; Gang Ji; Wang Ying; Tao Xu
Journal:  Protein Cell       Date:  2012-07-10       Impact factor: 14.870

9.  Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets.

Authors:  Peter Buchwald; Alejandro Tamayo-Garcia; Vita Manzoli; Alice A Tomei; Cherie L Stabler
Journal:  Biotechnol Bioeng       Date:  2017-09-19       Impact factor: 4.530

10.  Phosphorylation of SNAP-25 on serine-187 is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion.

Authors:  Carmen Gonelle-Gispert; Maria Costa; Masami Takahashi; Karin Sadoul; Philippe Halban
Journal:  Biochem J       Date:  2002-11-15       Impact factor: 3.857
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