Subcellular Ca(2+) Dynamics.

The field of subcellular Ca(2+) homeostasis is evolving rapidly. In parallel with improvements in spatial and temporal resolution of Ca(2+) imaging techniques, new methods using the natural cell machinery to target Ca(2+)-sensitive proteins such as aequorin to precise intracellular locations promise superb specificity to measure [Ca(2+)] in defined subcellular environments.