Literature DB >> 11390834

The Role of the Sinusoidal Endothelium in Liver Function.

Jürg Reichen1.   

Abstract

Microvascular exchange in the liver is governed by fenestrations in sinusoidal endothelial cells and can be manipulated pharmacologically. Microvascular exchange is affected in alcoholic liver disease and cirrhosis, the former leading to a loss of fenestrae, the latter to sinusoidal capillarization and thereby to loss of liver function in disease.

Entities:  

Year:  1999        PMID: 11390834     DOI: 10.1152/physiologyonline.1999.14.3.117

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN: 0886-1714


  18 in total

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Review 4.  The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance.

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Review 5.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
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7.  Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp.

Authors:  S V M Hordern; J E Wright; A M Umpleby; F Shojaee-Moradie; J Amiss; D L Russell-Jones
Journal:  Diabetologia       Date:  2005-02-24       Impact factor: 10.122

Review 8.  Anticoagulant therapy with the oral direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban and the thrombin inhibitor dabigatran etexilate in patients with hepatic impairment.

Authors:  Jochen Graff; Sebastian Harder
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Review 9.  Dynamic localization of hepatocellular transporters in health and disease.

Authors:  Marcelo G Roma; Fernando A Crocenzi; Aldo D Mottino
Journal:  World J Gastroenterol       Date:  2008-11-28       Impact factor: 5.742

Review 10.  Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction.

Authors:  Roger K Verbeeck
Journal:  Eur J Clin Pharmacol       Date:  2008-09-02       Impact factor: 2.953

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