Literature DB >> 11390795

Proteinase-Activated Receptors: New Functions for Old Enzymes.

Stephan K. Böhm1, Karen McConalogue, Wuyi Kong, Nigel W. Bunnett.   

Abstract

Although proteases are traditionally viewed as degradative enzymes, characterization of a family of G protein-coupled receptors that are activated by proteolysis reveals a new role. Certain proteases function as signaling molecules that specifically regulate cells by cleaving and activating a family of proteinase-activated receptors.

Year:  1998        PMID： 11390795     DOI： 10.1152/physiologyonline.1998.13.5.231

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  4 in total

1.  Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis.

Authors:  E S Michael; A Kuliopulos; L Covic; M L Steer; G Perides
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-12-28       Impact factor: 4.052

2.  The role of protease-activated receptor-2 (PAR2) in the modulation of beating of the mouse isolated ureter: lack of involvement of mast cells or sensory nerves.

Authors:  J D Moffatt; T M Cocks
Journal:  Br J Pharmacol       Date:  1999-10       Impact factor: 8.739

Review 3.  Abruption-associated prematurity.

Authors:  Christina S Han; Frederick Schatz; Charles J Lockwood
Journal:  Clin Perinatol       Date:  2011-09       Impact factor: 3.430

4.  Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro.

Authors:  Barden Chan; Vikas P Sukhatme
Journal:  Thromb Res       Date:  2008-09-03       Impact factor: 3.944
  4 in total

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