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Literature DB >> 11390769

Control of Upper Airway Motoneurons During REM Sleep.

Leszek Kubin¹, Richard O. Davies, Allan I. Pack.

Abstract

The loss of tone in upper airway muscles contributes to disorders of breathing during sleep. In an animal model of rapid eye movement sleep atonia, decrements in the activity of upper airway motoneurons are caused by withdrawal of excitation mediated by serotonin and other transmitters, rather than by state-dependent inhibition.

Entities: Chemical Disease

Year: 1998 PMID： 11390769 DOI： 10.1152/physiologyonline.1998.13.2.91

Source DB: PubMed Journal: News Physiol Sci ISSN： 0886-1714

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Cited

42 in total

1. GABAA receptor antagonism at the hypoglossal motor nucleus increases genioglossus muscle activity in NREM but not REM sleep.

Authors: Janna L Morrison; Sandeep Sood; Hattie Liu; Eileen Park; Philip Nolan; Richard L Horner
Journal: J Physiol Date: 2003-02-28 Impact factor: 5.182

Review 2. Breathing: rhythmicity, plasticity, chemosensitivity.

Authors: Jack L Feldman; Gordon S Mitchell; Eugene E Nattie
Journal: Annu Rev Neurosci Date: 2003-02-13 Impact factor: 12.449

3. Expiratory activation of abdominal muscle is associated with improved respiratory stability and an increase in minute ventilation in REM epochs of adult rats.

Authors: Colin G Andrews; Silvia Pagliardini
Journal: J Appl Physiol (1985) Date: 2015-09-03

4. The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial.

Authors: Luigi Taranto-Montemurro; Ludovico Messineo; Scott A Sands; Ali Azarbarzin; Melania Marques; Bradley A Edwards; Danny J Eckert; David P White; Andrew Wellman
Journal: Am J Respir Crit Care Med Date: 2019-05-15 Impact factor: 21.405

Control of Upper Airway Motoneurons During REM Sleep.

1. GABAA receptor antagonism at the hypoglossal motor nucleus increases genioglossus muscle activity in NREM but not REM sleep.

Review 2. Breathing: rhythmicity, plasticity, chemosensitivity.

3. Expiratory activation of abdominal muscle is associated with improved respiratory stability and an increase in minute ventilation in REM epochs of adult rats.

4. The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial.

5. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs.

6. Are all motoneurons created equal in the eyes of REM sleep and the mechanisms of muscle atonia?

7. Hypoglossal premotor neurons of the intermediate medullary reticular region express cholinergic markers.

Review 8. Sleep-disordered breathing in patients with neuromuscular disease.

9. Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus.

10. The modulation by 5-HT of glutamatergic inputs from the raphe pallidus to rat hypoglossal motoneurones, in vitro.