Literature DB >> 11390763

Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins.

Charalabos Pothoulakis1, Ignazio Castagliuolo, J. Thomas LaMont.   

Abstract

Experiments in intact animals exposed to enterotoxins demonstrate that neurons and immune cells of the lamina propria regulate toxin-induced diarrhea and tissue damage. Clostridium difficile toxins cause profound diarrhea and acute inflammation by activating a complex cascade initiated by toxin binding to enterocyte receptors.

Entities:  

Year:  1998        PMID： 11390763     DOI： 10.1152/physiologyonline.1998.13.2.58

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  18 in total

Review 1.  Update on gastrointestinal infections: Clostridium difficile and other bugs.

Authors:  C M Surawicz
Journal:  Curr Gastroenterol Rep       Date:  1999-10

2.  Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis.

Authors:  I C Cavalcante; M V Castro; A R F Barreto; G W Sullivan; M Vale; P R C Almeida; J Linden; J M Rieger; F Q Cunha; R L Guerrant; R A Ribeiro; G A C Brito
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

3.  Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia.

Authors:  Isabella Barajon; Graziano Serrao; Francesca Arnaboldi; Emanuela Opizzi; Gerlomina Ripamonti; Andrea Balsari; Cristiano Rumio
Journal:  J Histochem Cytochem       Date:  2009-06-22       Impact factor: 2.479

4.  Involvement of nerves and calcium channels in the intestinal response to Clostridium difficile toxin A: an experimental study in rats in vivo.

Authors:  J Sörensson; M Jodal; O Lundgren
Journal:  Gut       Date:  2001-07       Impact factor: 23.059

5.  Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B.

Authors:  Ralf Gerhard; Swenja Queisser; Helma Tatge; Gesa Meyer; Oliver Dittrich-Breiholz; Michael Kracht; Hanping Feng; Ingo Just
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-01-26       Impact factor: 3.000

6.  Clostridium difficile toxin A excites enteric neurones and suppresses sympathetic neurotransmission in the guinea pig.

Authors:  Y Xia; H Z Hu; S Liu; C Pothoulakis; J D Wood
Journal:  Gut       Date:  2000-04       Impact factor: 23.059

7.  Adenosine deaminase inhibition prevents Clostridium difficile toxin A-induced enteritis in mice.

Authors:  Ana Flávia Torquato de Araújo Junqueira; Adriana Abalen Martins Dias; Mariana Lima Vale; Graziela Machado Gruner Turco Spilborghs; Aline Siqueira Bossa; Bruno Bezerra Lima; Alex Fiorini Carvalho; Richard Littleton Guerrant; Ronaldo Albuquerque Ribeiro; Gerly Anne Brito
Journal:  Infect Immun       Date:  2010-11-29       Impact factor: 3.441

8.  Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.

Authors:  Graeme S Cottrell; Silvia Amadesi; Stella Pikios; Eric Camerer; J Adam Willardsen; Brett R Murphy; George H Caughey; Paul J Wolters; Shaun R Coughlin; Anders Peterson; Wolfgang Knecht; Charalabos Pothoulakis; Nigel W Bunnett; Eileen F Grady
Journal:  Gastroenterology       Date:  2007-04-13       Impact factor: 22.682

Review 9.  Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen.

Authors:  Milena M Awad; Priscilla A Johanesen; Glen P Carter; Edward Rose; Dena Lyras
Journal:  Gut Microbes       Date:  2014

10.  Ileal smooth muscle motility depression on rabbit induced by toxin A from Clostridium difficile.

Authors:  Crystianne Calado Lima; João Luis Carvalho-de-Souza; Aldo Angelo Moreira Lima; José Henrique Leal-Cardoso
Journal:  Dig Dis Sci       Date:  2008-06       Impact factor: 3.199
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