Literature DB >> 11390751

Renal Proximal Tubular Albumin Reabsorption: Daily Prevention of Albuminuria.

Michael Gekle1.   

Abstract

Although the glomerular filtration coefficient of albumin is small, the daily filtered load can be as much as 8 g. To prevent such massive losses of albumin, quantitative reabsorption along the proximal tubules is accomplished by "receptor"-mediated endocytosis. Albumin reaches the lysosomes where it is degraded to amino acids.

Entities:  

Year:  1998        PMID： 11390751     DOI： 10.1152/physiologyonline.1998.13.1.5

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  10 in total

1.  Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion.

Authors:  M Gekle; R Freudinger; S Mildenberger
Journal:  J Physiol       Date:  2001-03-15       Impact factor: 5.182

2.  Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum.

Authors:  M Gekle; K Drumm; S Mildenberger; R Freudinger; B Gassner; S Silbernagl
Journal:  J Physiol       Date:  1999-11-01       Impact factor: 5.182

3.  Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells.

Authors:  Michael Gekle; Petra Knaus; Rikke Nielsen; Sigrid Mildenberger; Ruth Freudinger; Verena Wohlfarth; Christoph Sauvant; Erik I Christensen
Journal:  J Physiol       Date:  2003-10-15       Impact factor: 5.182

4.  Kidney proximal tubular epithelial-specific overexpression of netrin-1 suppresses inflammation and albuminuria through suppression of COX-2-mediated PGE2 production in streptozotocin-induced diabetic mice.

Authors:  Riyaz Mohamed; Calpurnia Jayakumar; Punithavathi V Ranganathan; Vadivel Ganapathy; Ganesan Ramesh
Journal:  Am J Pathol       Date:  2012-10-02       Impact factor: 4.307

5.  Kidney Injury Molecule-1 Enhances Endocytosis of Albumin in Renal Proximal Tubular Cells.

Authors:  Xueying Zhao; Chen Jiang; Rebecca Olufade; Dong Liu; Nerimiah Emmett
Journal:  J Cell Physiol       Date:  2015-09-09       Impact factor: 6.384

6.  Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes.

Authors:  Calpurnia Jayakumar; Ferdau L Nauta; Stephan J L Bakker; Henk Bilo; Ron T Gansevoort; Maribeth H Johnson; Ganesan Ramesh
Journal:  J Nephrol       Date:  2014-02-08       Impact factor: 3.902

7.  Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes.

Authors:  Emre Ay; Kamile Marakoğlu; Muhammet Kizmaz; Ali Ünlü
Journal:  J Clin Lab Anal       Date:  2016-04-13       Impact factor: 2.352

8.  Microalbuminuria in normal Korean children.

Authors:  Byung Ok Kwak; Sang Taek Lee; Sochung Chung; Kyo Sun Kim
Journal:  Yonsei Med J       Date:  2011-05       Impact factor: 2.759

9.  Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips.

Authors:  Kimberly A Homan; David B Kolesky; Mark A Skylar-Scott; Jessica Herrmann; Humphrey Obuobi; Annie Moisan; Jennifer A Lewis
Journal:  Sci Rep       Date:  2016-10-11       Impact factor: 4.379

10.  Mediation of the relationship between proteinuria and serum phosphate: Insight from the KNOW-CKD study.

Authors:  Ji Yong Jung; Han Ro; Jae Hyun Chang; Ae Jin Kim; Hyun Hee Lee; Seung Hyeok Han; Tae-Hyun Yoo; Kyu-Beck Lee; Yeong Hoon Kim; Soo Wan Kim; Sue Kyung Park; Dong-Wan Chae; Kook-Hwan Oh; Curie Ahn; Wookyung Chung
Journal:  PLoS One       Date:  2020-06-22       Impact factor: 3.240
  10 in total

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