Literature DB >> 11389899

Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.

S Cho1, Y J Choi, J M Kim, S T Jeong, J H Kim, S H Kim, S E Ryu.   

Abstract

The hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1alpha regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1alpha. PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1alpha activity is associated with the proteasome pathway.

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Year:  2001        PMID： 11389899     DOI： 10.1016/s0014-5793(01)02499-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  A compendium of proteins that interact with HIF-1α.

Authors:  Gregg L Semenza
Journal:  Exp Cell Res       Date:  2017-03-20       Impact factor: 3.905

2.  SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.

Authors:  Marco Montagner; Elena Enzo; Mattia Forcato; Francesca Zanconato; Anna Parenti; Elena Rampazzo; Giuseppe Basso; Genesio Leo; Antonio Rosato; Silvio Bicciato; Michelangelo Cordenonsi; Stefano Piccolo
Journal:  Nature       Date:  2012-07-19       Impact factor: 49.962

3.  Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells.

Authors:  Alexandre F Fernandes; Weimin Guo; Xinyu Zhang; Matthew Gallagher; Mircea Ivan; Allen Taylor; Paulo Pereira; Fu Shang
Journal:  Exp Eye Res       Date:  2006-10-05       Impact factor: 3.467

4.  Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha.

Authors:  Xianguo Kong; Zhao Lin; Dongming Liang; Donna Fath; Nianli Sang; Jaime Caro
Journal:  Mol Cell Biol       Date:  2006-03       Impact factor: 4.272

5.  Validation of an engineered cell model for in vitro and in vivo HIF-1α evaluation by different imaging modalities.

Authors:  A Lo Dico; S Valtorta; C Martelli; S Belloli; U Gianelli; D Tosi; S Bosari; A Degrassi; M Russo; I Raccagni; G Lucignani; R M Moresco; L Ottobrini
Journal:  Mol Imaging Biol       Date:  2014-04       Impact factor: 3.488

Review 6.  Negative regulators of the RIG-I-like receptor signaling pathway.

Authors:  Kendra M Quicke; Michael S Diamond; Mehul S Suthar
Journal:  Eur J Immunol       Date:  2017-04       Impact factor: 5.532

Review 7.  Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target.

Authors:  Randy L Jensen
Journal:  J Neurooncol       Date:  2009-04-09       Impact factor: 4.130

8.  Evolution and regulation of the downstream gene of hypoxia-inducible factor-1alpha in naked carp (Gymnocypris przewalskii) from Lake Qinghai, China.

Authors:  Yi-Bin Cao; Xue-Qun Chen; Shen Wang; Yu-Xiang Wang; Ji-Zeng Du
Journal:  J Mol Evol       Date:  2008-10-22       Impact factor: 2.395

9.  Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

Authors:  Ping Yi; Qin Feng; Larbi Amazit; David M Lonard; Sophia Y Tsai; Ming-Jer Tsai; Bert W O'Malley
Journal:  Mol Cell       Date:  2008-02-29       Impact factor: 17.970

10.  COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.

Authors:  Bart van de Sluis; Arjan J Groot; Jeroen Vermeulen; Elsken van der Wall; Paul J van Diest; Cisca Wijmenga; Leo W Klomp; Marc Vooijs
Journal:  PLoS One       Date:  2009-10-05       Impact factor: 3.240
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