Literature DB >> 11388862

Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase.

G M Nicholas1, G L Newton, R C Fahey, C A Bewley.   

Abstract

[structure: see text] The novel alkaloids 1 and 4 were isolated from an Australian non-verongid sponge, Oceanapia sp. Compound 1 contains an unprecedented imidazolyl-quinolinone substructure attached to a bromotyrosine-derived spiro-isoxazoline. Three other known alkaloids were isolated in addition to 1 and 4 and together represent the first examples of inhibitors of a new mycobacterial enzyme mycothiol S-conjugate amidase (MCA).

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Year:  2001        PMID： 11388862     DOI： 10.1021/ol015845+

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  12 in total

Review 1.  The marine bromotyrosine derivatives.

Authors:  Jiangnan Peng; Jing Li; Mark T Hamann
Journal:  Alkaloids Chem Biol       Date:  2005

Review 2.  Status and perspective of sponge chemosystematics.

Authors:  Dirk Erpenbeck; Rob W M van Soest
Journal:  Mar Biotechnol (NY)       Date:  2006-07-03       Impact factor: 3.619

3.  Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates.

Authors:  John M Knapp; James C Fettinger; Mark J Kurth
Journal:  Org Lett       Date:  2011-08-09       Impact factor: 6.005

Review 4.  New targets and inhibitors of mycobacterial sulfur metabolism.

Authors:  Hanumantharao Paritala; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2013-04

5.  Total Synthesis and Biological Evaluation of Clavatadines C-E.

Authors:  Kylee Maxfield; Morgan Payne; Stephen Chamberland
Journal:  ACS Omega       Date:  2022-06-22

6.  Microbial and Functional Biodiversity Patterns in Sponges that Accumulate Bromopyrrole Alkaloids Suggest Horizontal Gene Transfer of Halogenase Genes.

Authors:  Cintia P J Rua; Louisi S de Oliveira; Adriana Froes; Diogo A Tschoeke; Ana Carolina Soares; Luciana Leomil; Gustavo B Gregoracci; Ricardo Coutinho; Eduardo Hajdu; Cristiane C Thompson; Roberto G S Berlinck; Fabiano L Thompson
Journal:  Microb Ecol       Date:  2018-03-15       Impact factor: 4.552

Review 7.  Drug targets in mycobacterial sulfur metabolism.

Authors:  Devayani P Bhave; Wilson B Muse; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2007-06

8.  A Model Study toward the Concise Synthesis of Bromotyrosine Derived Spiroisoxazoline Natural Products and Analogous Core Structures.

Authors:  Prasanta Das; Edward J Valente; Ashton T Hamme
Journal:  European J Org Chem       Date:  2014-05-01

Review 9.  Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

Authors:  Gerald L Newton; Nancy Buchmeier; Robert C Fahey
Journal:  Microbiol Mol Biol Rev       Date:  2008-09       Impact factor: 11.056

10.  Functional characterization of Corynebacterium glutamicum mycothiol S-conjugate amidase.

Authors:  Meiru Si; Mingxiu Long; Muhammad Tausif Chaudhry; Yixiang Xu; Pan Zhang; Lei Zhang; Xihui Shen
Journal:  PLoS One       Date:  2014-12-16       Impact factor: 3.240
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