Upregulation of duodenal calcium absorption by poly-unsaturated fatty acids: events at the basolateral membrane.

Poly-unsaturated fatty acids, especially of the n-3 series, have a beneficial effect in treatment of osteoporosis in the elderly. Duodenal calcium absorption is a particularly vulnerable aspect of the development of this disease. It has been shown that the process of calcium transport through the rat duodenal enterocyte takes place in essentially three steps: entry of calcium through channels in the brush border (apical membrane), transcellular transport through the cytoplasm by calbindin and extrusion at the basolateral membrane by Ca(2+)-ATPase and a Ca(2+)-Na(+)exchanger which is driven by Na(+), K(+)-ATPase. This paper presents a hypothesis that poly-unsaturated fatty acids can modulate both Ca(2+)-ATPase and Na(+), K(+)-ATPase activity either by a direct action on the enzyme or by phosphorylation processes via protein kinases A and C and thus exert their positive influence on calcium absorption in this manner. Copyright 2001 Harcourt Publishers Ltd.