Literature DB >> 11388478

Anti-tumor promoting activity of bufadienolides from Kalanchoe pinnata and K. daigremontiana x tubiflora.

U Supratman1, T Fujita, K Akiyama, H Hayashi, A Murakami, H Sakai, K Koshimizu, H Ohigashi.   

Abstract

Five bufadienolides (1-5) isolated from the leaves of Kalanchoe pinnata and K. daigremontiana x tubiflora (Crassulaceae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. All bufadienolides showed inhibitory activity, and bryophyllin A (1) exhibited the most marked inhibition (IC50 = 0.4 microM) among the tested compounds. Bryophyllin C (2), a reduction analogue of 1, and bersaldegenin-3-acetate (3) lacking the orthoacetate moiety were less active. These results strongly suggest that bufadienolides are potential cancer chemopreventive agents.

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Year:  2001        PMID： 11388478     DOI： 10.1271/bbb.65.947

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  23 in total

1.  Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants.

Authors:  Chutima Kaewpiboon; Kriengsak Lirdprapamongkol; Chantragan Srisomsap; Pakorn Winayanuwattikun; Tikamporn Yongvanich; Preecha Puwaprisirisan; Jisnuson Svasti; Wanchai Assavalapsakul
Journal:  BMC Complement Altern Med       Date:  2012-11-13       Impact factor: 3.659

2.  Antiviral Ability of Kalanchoe gracilis Leaf Extract against Enterovirus 71 and Coxsackievirus A16.

Authors:  Ching-Ying Wang; Shun-Chueh Huang; Yongjun Zhang; Zhen-Rung Lai; Szu-Hao Kung; Yuan-Shiun Chang; Cheng-Wen Lin
Journal:  Evid Based Complement Alternat Med       Date:  2012-05-15       Impact factor: 2.629

3.  Anticancer property of Bryophyllum pinnata (Lam.) Oken. leaf on human cervical cancer cells.

Authors:  Sutapa Mahata; Saurabh Maru; Shirish Shukla; Arvind Pandey; G Mugesh; Bhudev C Das; Alok C Bharti
Journal:  BMC Complement Altern Med       Date:  2012-03-10       Impact factor: 3.659

4.  An In Vitro Anticancer, Antioxidant, and Phytochemical Study on Water Extract of Kalanchoe daigremontiana Raym.-Hamet and H. Perrier.

Authors:  Justyna Stefanowicz-Hajduk; Anna Hering; Magdalena Gucwa; Katarzyna Sztormowska-Achranowicz; Mariusz Kowalczyk; Agata Soluch; J Renata Ochocka
Journal:  Molecules       Date:  2022-03-31       Impact factor: 4.411

5.  Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz.

Authors:  Abhishek L Sharma; Meeta A Bhot; Naresh Chandra
Journal:  Anc Sci Life       Date:  2014 Apr-Jun

6.  Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom.

Authors:  Júlia Morais Fernandes; Juliana Félix-Silva; Lorena Medeiros da Cunha; Jacyra Antunes Dos Santos Gomes; Emerson Michell da Silva Siqueira; Luisa Possamai Gimenes; Norberto Peporine Lopes; Luiz Alberto Lira Soares; Matheus de Freitas Fernandes-Pedrosa; Silvana Maria Zucolotto
Journal:  PLoS One       Date:  2016-12-29       Impact factor: 3.240

7.  Immunomodulating and Revascularizing Activity of Kalanchoe pinnata Synergize with Fungicide Activity of Biogenic Peptide Cecropin P1.

Authors:  N S Zakharchenko; A S Belous; Y K Biryukova; O A Medvedeva; A V Belyakova; G A Masgutova; E V Trubnikova; Y I Buryanov; A A Lebedeva
Journal:  J Immunol Res       Date:  2017-06-11       Impact factor: 4.818

8.  Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus.

Authors:  Yi-Jen Hsieh; Ming-Yeh Yang; Yann-Lii Leu; Chinpiao Chen; Chin-Fung Wan; Meng-Ya Chang; Chih-Jui Chang
Journal:  BMC Complement Altern Med       Date:  2012-09-10       Impact factor: 3.659

9.  Plant Growth-Promoting Rhizobacteria Stimulate Vegetative Growth and Asexual Reproduction of Kalanchoe daigremontiana.

Authors:  Yong-Soon Park; Kyungseok Park; Joseph W Kloepper; Choong-Min Ryu
Journal:  Plant Pathol J       Date:  2015-09-30       Impact factor: 1.795

10.  Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi.

Authors:  Apexa Bhanuprasad Shukla; Divyesh Rasikbhai Mandavia; Manish Jasmatbhai Barvaliya; Seema Natvarlal Baxi; Chandrabhanu Rajkishore Tripathi
Journal:  Avicenna J Phytomed       Date:  2014-05
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