Literature DB >> 11387479

Structure of complement receptor 2 in complex with its C3d ligand.

G Szakonyi1, J M Guthridge, D Li, K Young, V M Holers, X S Chen.   

Abstract

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

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Year:  2001        PMID： 11387479     DOI： 10.1126/science.1059118

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  47 in total

1.  Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus).

Authors:  Isabell C Pechtl; Robert K Neely; David T F Dryden; Anita C Jones; Paul N Barlow
Journal:  Protein Sci       Date:  2011-12       Impact factor: 6.725

Review 2.  Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium.

Authors:  Ross M Kedl; Beth A Tamburini
Journal:  Eur J Immunol       Date:  2015-09-10       Impact factor: 5.532

Review 3.  Complement receptors and the shaping of the natural antibody repertoire.

Authors:  V Michael Holers
Journal:  Springer Semin Immunopathol       Date:  2004-12-22

4.  A structural model reveals energy transduction in dynein.

Authors:  Adrian W R Serohijos; Yiwen Chen; Feng Ding; Timothy C Elston; Nikolay V Dokholyan
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-22       Impact factor: 11.205

Review 5.  Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity.

Authors:  Franklin R Toapanta; Ted M Ross
Journal:  Immunol Res       Date:  2006       Impact factor: 2.829

6.  Immunophysical properties and prediction of activities for vaccinia virus complement control protein and smallpox inhibitor of complement enzymes using molecular dynamics and electrostatics.

Authors:  Li Zhang; Dimitrios Morikis
Journal:  Biophys J       Date:  2006-02-10       Impact factor: 4.033

7.  The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation.

Authors:  Vengadesan Krishnan; Yuanyuan Xu; Kevin Macon; John E Volanakis; Sthanam V L Narayana
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-02-20

8.  Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies.

Authors:  Linda Mark; David G Proctor; David J Blackbourn; Anna M Blom; O Brad Spiller
Journal:  Immunology       Date:  2007-08-30       Impact factor: 7.397

9.  Amino acid patterns within short consensus repeats define conserved duplicons shared by genes of the RCA complex.

Authors:  Craig A McLure; Roger L Dawkins; Joseph F Williamson; Richard A Davies; Jemma Berry; Longman-Jacobsen Natalie; Rebecca Laird; Silvana Gaudieri
Journal:  J Mol Evol       Date:  2004-08       Impact factor: 2.395

10.  The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.

Authors:  Andrea E Prota; David R Sage; Thilo Stehle; Joyce D Fingeroth
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-16       Impact factor: 11.205
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