Literature DB >> 11384869

Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells.

H Rochefort1, D Chalbos, S Cunat, A Lucas, N Platet, M Garcia.   

Abstract

Cathepsin D (cath-D), an estrogen-regulated protease appears mostly to increase the number of tumor cells rather than their invasion or motility through the extracellular matrix. Estradiol is mitogenic but in vitro it also inhibits invasion and motility. In this review, we discuss the mechanism of this inhibition and the hormonal regulation of other proteases and protease inhibitors possibly involved in the control of tumor cell invasion by estrogens.

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Year:  2001        PMID： 11384869     DOI： 10.1016/s0960-0760(00)00142-4

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN： 0960-0760            Impact factor:   4.292


  8 in total

1.  Acid treatment of melanoma cells selects for invasive phenotypes.

Authors:  Raymond E Moellering; Kvar C Black; Chetan Krishnamurty; Brenda K Baggett; Phillip Stafford; Matthew Rain; Robert A Gatenby; Robert J Gillies
Journal:  Clin Exp Metastasis       Date:  2008-02-27       Impact factor: 5.150

2.  MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer.

Authors:  Karina E Hew; Philip C Miller; Dorraya El-Ashry; Jun Sun; Alexandra H Besser; Tan A Ince; Mengnan Gu; Zhi Wei; Gao Zhang; Patricia Brafford; Wei Gao; Yiling Lu; Gordon B Mills; Joyce M Slingerland; Fiona Simpkins
Journal:  Clin Cancer Res       Date:  2015-10-19       Impact factor: 12.531

3.  Requirement for stromal estrogen receptor alpha in cervical neoplasia.

Authors:  Sang-Hyuk Chung; Myeong Kyun Shin; Kenneth S Korach; Paul F Lambert
Journal:  Horm Cancer       Date:  2012-10-13       Impact factor: 3.869

Review 4.  Hormone response in ovarian cancer: time to reconsider as a clinical target?

Authors:  Francesmary Modugno; Robin Laskey; Ashlee L Smith; Courtney L Andersen; Paul Haluska; Steffi Oesterreich
Journal:  Endocr Relat Cancer       Date:  2012-11-09       Impact factor: 5.678

Review 5.  New insights on the role of hormonal therapy in ovarian cancer.

Authors:  Fiona Simpkins; Arlene Garcia-Soto; Joyce Slingerland
Journal:  Steroids       Date:  2013-02-08       Impact factor: 2.668

Review 6.  Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.

Authors:  Gaetano Leto; Francesca M Tumminello; Marilena Crescimanno; Carla Flandina; Nicola Gebbia
Journal:  Clin Exp Metastasis       Date:  2004       Impact factor: 5.150

7.  N-terminal prolactin-derived fragments, vasoinhibins, are proapoptoptic and antiproliferative in the anterior pituitary.

Authors:  Jimena Ferraris; Daniela Betiana Radl; Sandra Zárate; Gabriela Jaita; Guadalupe Eijo; Verónica Zaldivar; Carmen Clapp; Adriana Seilicovich; Daniel Pisera
Journal:  PLoS One       Date:  2011-07-07       Impact factor: 3.240

Review 8.  Endometriosis-Associated Macrophages: Origin, Phenotype, and Function.

Authors:  Chloe Hogg; Andrew W Horne; Erin Greaves
Journal:  Front Endocrinol (Lausanne)       Date:  2020-01-23       Impact factor: 5.555
  8 in total

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