Literature DB >> 11383912

Type I 5'-iodothyronine deiodinase activity and mRNA are remarkably reduced in renal clear cell carcinoma.

J Pachucki1, M Ambroziak, Z Tanski, J Luczak, J Nauman, A Nauman.   

Abstract

The purpose of this study was to compare thyroid hormone metabolism between non-cancerous tumor-surrounding human kidney tissues and renal clear cell carcinomas (RCCC). The material consisted of samples taken from 10 RCCC patients of both sexes and three grades of differentiation, G1 to G3. We showed that, similar to rat tissue, type I 5' monodeiodinase (5'DI) expression is heterogeneous within the human kidney. We also found a poor correlation between 5'DI activity and mRNA level in non-cancerous tumor-surrounding tissue suggesting significant post-transcriptional regulation of 5'DI expression by an unidentified process in the human kidney. In all RCCC tissues both 5'DI activity and mRNA levels were undetectable. This suggests either loss of human 5'DI gene expression during neoplastic transformation or the origination of RCCC from a tubular cell type that does not express 5'DI.

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Year:  2001        PMID： 11383912     DOI： 10.1007/BF03343855

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  48 in total

1.  Inflammatory cytokines and type I 5'-deiodinase expression in phi1 rat liver cells.

Authors:  P H Davies; M C Sheppard; J A Franklyn
Journal:  Mol Cell Endocrinol       Date:  1997-05-16       Impact factor: 4.102

Review 2.  Transcription-factor mutations and disease.

Authors:  D S Latchman
Journal:  N Engl J Med       Date:  1996-01-04       Impact factor: 91.245

3.  The type I iodothyronine 5'-deiodinase messenger ribonucleic acid is localized to the S3 segment of the rat kidney proximal tubule.

Authors:  W S Lee; M J Berry; M A Hediger; P R Larsen
Journal:  Endocrinology       Date:  1993-05       Impact factor: 4.736

4.  The promoter of the human type I 5'-deiodinase gene--mapping of the transcription start site and identification of a DR+4 thyroid-hormone-responsive element.

Authors:  T C Jakobs; C Schmutzler; J Meissner; J Köhrle
Journal:  Eur J Biochem       Date:  1997-07-01

5.  [Monodeiodination of thyroxine to 3,3', 5-triiodothyronine and 3,3', 5'-triiodothyronine in human kidney homogenate (author's transl)].

Authors:  K Yoshida; T Sakurada; H Kitaoka; H Fukazawa; N Kaise; K Kaise; M Yamamoto; M Suzuki; S Saito; K Yoshinaga; S Kimura; M Yamanaka
Journal:  Nihon Naibunpi Gakkai Zasshi       Date:  1982-03-20

6.  Outcome of severe congenital hypothyroidism: closing the developmental gap with early high dose levothyroxine treatment.

Authors:  J M Dubuis; J Glorieux; F Richer; C L Deal; J H Dussault; G Van Vliet
Journal:  J Clin Endocrinol Metab       Date:  1996-01       Impact factor: 5.958

7.  Regulation of iodothyronine 5'-deiodinases: effects of thiol blockers and altered substrate levels in vivo and in vitro.

Authors:  A Goswami; I N Rosenberg
Journal:  Endocrinology       Date:  1990-05       Impact factor: 4.736

8.  Crucial role of thyroid hormone in x-ray-induced neoplastic transformation in cell culture.

Authors:  D L Guernsey; C Borek; I S Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

9.  Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines.

Authors:  R Schreck; F Schnieders; C Schmutzler; J Köhrle
Journal:  J Clin Endocrinol Metab       Date:  1994-09       Impact factor: 5.958

10.  Effects of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 on type I iodothyronine 5'-deiodination in rat thyroid cell line, FRTL-5.

Authors:  H Hashimoto; N Igarashi; T Miyawaki; T Sato
Journal:  J Interferon Cytokine Res       Date:  1995-04       Impact factor: 2.607
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  12 in total

1.  Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters.

Authors:  Valmara S Pereira; Michelle P Marassi; Doris Rosenthal; Mário Vaisman; Vânia M Corrêa da Costa
Journal:  Endocrine       Date:  2011-12-30       Impact factor: 3.633

Review 2.  Iodothyronine deiodinases and cancer.

Authors:  A Piekiełko-Witkowska; A Nauman
Journal:  J Endocrinol Invest       Date:  2011-05-27       Impact factor: 4.256

Review 3.  Deiodinases and their intricate role in thyroid hormone homeostasis.

Authors:  Cristina Luongo; Monica Dentice; Domenico Salvatore
Journal:  Nat Rev Endocrinol       Date:  2019-08       Impact factor: 43.330

4.  MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.

Authors:  Joanna Boguslawska; Anna Wojcicka; Agnieszka Piekielko-Witkowska; Adam Master; Alicja Nauman
Journal:  PLoS One       Date:  2011-09-02       Impact factor: 3.240

5.  Thyroid hormone deiodinases and cancer.

Authors:  Sabina Casula; Antonio C Bianco
Journal:  Front Endocrinol (Lausanne)       Date:  2012-06-01       Impact factor: 5.555

6.  Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors.

Authors:  Oskar Kornasiewicz; Marcin Dębski; Michal Grat; Barbara Lenartowicz; Marta Stępnowska; Anna Szałas; Ewa Bar-Andziak; Marek Krawczyk
Journal:  Arch Med Sci       Date:  2013-08-20       Impact factor: 3.318

7.  Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system.

Authors:  Piotr Popławski; Jacek R Wiśniewski; Eddy Rijntjes; Keith Richards; Beata Rybicka; Josef Köhrle; Agnieszka Piekiełko-Witkowska
Journal:  PLoS One       Date:  2017-12-22       Impact factor: 3.240

8.  The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study.

Authors:  Oskar Kornasiewicz; Marcin Debski; Marta Stepnowska; Anna Szałas; Ewa Bar-Andziak; Marek Krawczyk
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2010-01-05       Impact factor: 4.291

9.  Thyroid hormone - triiodothyronine - has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) - role of E2F4, E2F5 and p107, p130.

Authors:  Piotr Poplawski; Alicja Nauman
Journal:  Thyroid Res       Date:  2008-10-13

Review 10.  Thyroid Hormones as Renal Cell Cancer Regulators.

Authors:  Łukasz Szymański; Damian Matak; Ewa Bartnik; Cezary Szczylik; Anna M Czarnecka
Journal:  J Signal Transduct       Date:  2016-03-13
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