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Literature DB >> 11383325

PPAR gamma: an essential role in metabolic control.

Abstract

The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.

Entities: Chemical Gene

Mesh：

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Year: 2001 PMID： 11383325

Source DB: PubMed Journal: Nutr Metab Cardiovasc Dis ISSN： 0939-4753 Impact factor: 4.222

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Cited

17 in total

1. Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.

Authors: Avani A Pendse; Lance A Johnson; Hyung-Suk Kim; Marcus McNair; C Taylor Nipp; Carolyn Wilhelm; Nobuyo Maeda
Journal: Arterioscler Thromb Vasc Biol Date: 2012-04-26 Impact factor: 8.311

2. Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD).

Authors: Yuanquan Song; Mary A Selak; Corey T Watson; Christopher Coutts; Paul C Scherer; Jessica A Panzer; Sarah Gibbs; Marion O Scott; Gregory Willer; Ronald G Gregg; Declan W Ali; Michael J Bennett; Rita J Balice-Gordon
Journal: PLoS One Date: 2009-12-17 Impact factor: 3.240

3. Quantitative assessment of the influence of PPARG P12A polymorphism on gestational diabetes mellitus risk.

Authors: Caiyan Wang; Xiaotian Li; Zirong Huang; Jinfeng Qian
Journal: Mol Biol Rep Date: 2012-10-11 Impact factor: 2.316

4. Genetic variation in TNFα, PPARγ, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort.

Authors: Catherine Duggan; Richard N Baumgartner; Kathy B Baumgartner; Leslie Bernstein; Stephanie George; Rachel Ballard; Marian L Neuhouser; Anne McTiernan
Journal: Breast Cancer Res Treat Date: 2017-12-18 Impact factor: 4.872

5. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes.

Authors: Hong Wang; Li Qiang; Stephen R Farmer
Journal: Mol Cell Biol Date: 2007-10-22 Impact factor: 4.272

PPAR gamma: an essential role in metabolic control.

1. Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.

2. Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD).

3. Quantitative assessment of the influence of PPARG P12A polymorphism on gestational diabetes mellitus risk.

4. Genetic variation in TNFα, PPARγ, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort.

5. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes.

Review 6. Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity.

Review 7. The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.

8. Reprogramming of the circadian clock by nutritional challenge.

9. Dietary fructose-related adiposity and glucocorticoid receptor function in visceral adipose tissue of female rats.

Review 10. Emerging drugs for the treatment of ulcerative colitis.