Literature DB >> 1138297

A mass fragmentographic method for the quantitative evaluation of brain prostaglandin biosynthesis.

S Nicosia, G Galli.   

Abstract

A method for the evaluation of PGF-2alpha and PGE-2 biosynthesis in rat cerebral cortex is described. Tissue slices were incubated without any added precursor for different lengths of time. The analytical procedure involves prostaglandin extraction, purification and quantitative determination by mass fragmentography. Significant amounts of both prostaglandins were synthesized. The biosynthesis reached a plateau after 30 minutes and the ratio of PGF-2alpha to PGE-2 was approximately 3.

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Year:  1975        PMID： 1138297     DOI： 10.1016/0090-6980(75)90145-8

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  4 in total

1.  Cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis.

Authors:  P G Weston; P V Johnston
Journal:  Lipids       Date:  1978-06       Impact factor: 1.880

2.  delta-9-tetrahydrocannabinol (THC) increases brain prostaglandins in the rat.

Authors:  S K Bhattacharya
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

3.  The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.

Authors:  H B Steinhauer; H Anhut; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

4.  Regional distribution of prostanoids in rat brain: effect of insulin and 2-deoxyglucose.

Authors:  E Shohami; M Globus; J Weidenfeld
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972
  4 in total

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