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Literature DB >> 113824

Cortexolone antagonizes development of alcohol tolerance in mice.

Abstract

Mice treated with cortexolone during a period of chronic ethanol feeding displayed significantly less tolerance to a challenge dose of ethanol than mice fed ethanol but not given cortexolone. This glucocorticoid receptor blocker did not alter the hypnotic effects of ethanol in animals not previously given ethanol and no differences were found in ethanol consumption or blood ethanol levels between ethanol-fed mice receiving daily injections of cortexolone and the vehicle-injected controls. It was concluded that cortexolone interferes with the development of tolerance to ethanol.

Entities: Chemical Species

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Year: 1979 PMID： 113824 DOI： 10.1007/bf00427357

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

8 in total

1. Role of cholinergic and glucocorticosteroid receptors in the tyrosine hydroxylase induction elicited by reserpine in superior cervical ganglion.

Authors: I Hanbauer; W Lovenberg; A Guidotti; E Costa
Journal: Brain Res Date: 1975-10-10 Impact factor: 3.252

2. Corticosterone concentrations in mice during ethanol drinking and withdrawal.

Authors: B Tabakoff; R C Jafee; R F Ritzmann
Journal: J Pharm Pharmacol Date: 1978-06 Impact factor: 3.765

3. Adrenal glucocorticoids as a required factor in the development of ethanol withdrawal seizures in mice.

Authors: P Y Sze; J Yanai; B E Ginsburg
Journal: Brain Res Date: 1974-11-08 Impact factor: 3.252

4. Specific binding of cortisol in subcellular fractions of HeLa cells: temperature dependence and effects of inhibitors.

Authors: G Melnykovych; C F Bishop
Journal: Endocrinology Date: 1971-02 Impact factor: 4.736

1 in total

1. Altered sensitivity to ethanol following prenatal exposure to barbiturate.

Authors: J Yanai; B Tabakoff
Journal: Psychopharmacology (Berl) Date: 1980 Impact factor: 4.530

1 in total

Cortexolone antagonizes development of alcohol tolerance in mice.

1. Role of cholinergic and glucocorticosteroid receptors in the tyrosine hydroxylase induction elicited by reserpine in superior cervical ganglion.

2. Corticosterone concentrations in mice during ethanol drinking and withdrawal.

3. Adrenal glucocorticoids as a required factor in the development of ethanol withdrawal seizures in mice.

4. Specific binding of cortisol in subcellular fractions of HeLa cells: temperature dependence and effects of inhibitors.

5. The effects of 6-hydroxydopamine on tolerance to and dependence on ethanol.

6. Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.

7. Facilitation by dexamethasone of tolerance to ethanol in the rat.

8. Effect of p-chlorophenylalnine on the loss and maintenance of tolerance to ethanol.

1. Altered sensitivity to ethanol following prenatal exposure to barbiturate.