Literature DB >> 11382201

Long-term treatment with idebenone and riboflavin in a patient with MELAS.

A Napolitano1, S Salvetti, M Vista, V Lombardi, G Siciliano, C Giraldi.   

Abstract

We report a patient with MELAS treated for 24 months with idebenone and riboflavin, during which no stroke-like episodes occurred. Moreover neurological symptoms clearly improved, and a recovery of brain MRI and EEG abnormalities was observed. We conclude that the combined treatment with idebenone and riboflavin may restore the metabolic impairment in MELAS, possibly improving the long-term prognosis in these patients.

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Year:  2000        PMID： 11382201     DOI： 10.1007/s100720070015

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  16 in total

Review 1.  The mitochondrial myopathy encephalopathy, lactic acidosis with stroke-like episodes (MELAS) syndrome: a review of treatment options.

Authors:  Fernando Scaglia; Jennifer L Northrop
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

2.  Single gene disorders associated with stroke: a review and update on treatment options.

Authors:  Hurmina Muqtadar; Fernando D Testai
Journal:  Curr Treat Options Cardiovasc Med       Date:  2012-06

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Journal:  Mol Genet Metab       Date:  2016-07-16       Impact factor: 4.797

4.  Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia.

Authors:  K V Voronkova; M N Meleshkov
Journal:  Neurosci Behav Physiol       Date:  2009-06

5.  How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs.

Authors:  Brígida R Pinho; Miguel M Santos; Anabela Fonseca-Silva; Patrícia Valentão; Paula B Andrade; Jorge M A Oliveira
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6.  Mitochondrial respiration without ubiquinone biosynthesis.

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7.  Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I.

Authors:  Michael Erb; Barbara Hoffmann-Enger; Holger Deppe; Michael Soeberdt; Roman H Haefeli; Christian Rummey; Achim Feurer; Nuri Gueven
Journal:  PLoS One       Date:  2012-04-27       Impact factor: 3.240

8.  NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels.

Authors:  Roman H Haefeli; Michael Erb; Anja C Gemperli; Dimitri Robay; Isabelle Courdier Fruh; Corinne Anklin; Robert Dallmann; Nuri Gueven
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

9.  The effects of idebenone on mitochondrial bioenergetics.

Authors:  Valentina Giorgio; Valeria Petronilli; Anna Ghelli; Valerio Carelli; Michela Rugolo; Giorgio Lenaz; Paolo Bernardi
Journal:  Biochim Biophys Acta       Date:  2011-11-04

10.  Multiple neurologic, psychiatric, and endocrine complaints in a young woman: a case discussion and review of the clinical features and management of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke.

Authors:  Chaya G Bhuvaneswar; Jared L Goetz; Theodore A Stern
Journal:  Prim Care Companion J Clin Psychiatry       Date:  2008
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