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Literature DB >> 11381627

Spontaneous neoplastic lesions in aged Sprague-Dawley rats.

M Nakazawa¹, T Tawaratani, H Uchimoto, A Kawaminami, M Ueda, A Ueda, Y Shinoda, K Iwakura, K Kura, N Sumi.

Abstract

Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.

Entities: Disease Species

Mesh：

Year: 2001 PMID： 11381627 DOI： 10.1538/expanim.50.99

Source DB: PubMed Journal: Exp Anim ISSN： 0007-5124

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Cited

14 in total

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Spontaneous neoplastic lesions in aged Sprague-Dawley rats.

1. Hyaluronic Acid/Collagen Hydrogel as an Alternative to Alginate for Long-Term Immunoprotected Islet Transplantation<sup/>.

2. Biological tolerance of different materials in bulk and nanoparticulate form in a rat model: sarcoma development by nanoparticles.

Review 3. Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.

4. Dietary nucleotides extend the life span in Sprague-Dawley rats.

5. Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findings.

6. Natural occurrence of neoplastic lesions in young sprague-dawley rats.

7. A case of metastatic adrenocortical carcinoma diagnosed with steroidogenic factor-1 in a sprague-dawley rat.

8. Spontaneous nephroblastoma with oncocytic differentiation in a Japanese White rabbit.

9. A spontaneously occurring malignant pituicytoma in a male sprague dawley rat.

10. Stress-reactive rats (high-avoidance female rats) have a shorter lifespan than stress-nonreactive rats (low-avoidance female rats).